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MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim

MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim. dorsal horn of the spinal cord. CGRP: calcitonin gene related peptide; 5-HT: serotonin. capsaicin. VR-1: vanilloid receptor type 1. C. D. Kandel Fig. 24-4. synapse of a C-fiber (“C”) on the dendrite (“D”)

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MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim

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  1. MEDS 371, Systems Neuroscience Pain System Dr. D. O. Kim

  2. dorsal horn of the spinal cord

  3. CGRP: calcitonin gene related peptide; 5-HT: serotonin

  4. capsaicin VR-1: vanilloid receptor type 1

  5. C D Kandel Fig. 24-4 synapse of a C-fiber (“C”) on the dendrite (“D”) of a dorsal-horn neuron. small vesicles: glutamate; large vesicles: neuropeptides.

  6. discriminative pain pathways (except face/head) anterolateral system (ALS); spinothalamic tract

  7. spinal-cord hemisection Brown-Sequard’s syndrome section at lumbar spinal cord Purves

  8. trigem gang discriminative pain pathways: face/head trigemino- thalamic tract

  9. trigeminal pathways somatosensory cortex principal trigem. sensory nucleus trigemino- thalamic tract pons trigeminal ganglion spinal trigem. tract & nucleus medulla Haines Fig 8-9

  10. affect: n. the conscious subjective aspect of an emotion apart from bodily changes. [Webster’s New Collegiate Dictionary]

  11. Two distinct aspects of the experience of pain thalamic nuclei: midline; anterior; mediodorsal modified from Purves Fig 10-5

  12. thamaic nuclei Netter CM: centromedian; LD: laterodorsal; LP: lateroposterior; MD: mediodorsal; VA: ventral anterior; VL: ventral lateral; VPL: ventral posterolateral; VPM: ventral posteromedial

  13. thalamus cingulate cortex hypothalamus Purves Fig. A-12

  14. insula Purves Fig. A-10

  15. affective pain pathways; unpleasant quality of pain

  16. endogenous opioids: enkephalin; dynorphin; endorphin; in midbrain periaqueductal gray rost. vent. medulla spinal cord

  17. descending control of pain pathways hypothalamus Kandel Fig 24-11

  18. descending control of pain pathways Purves Fig 10-8B

  19. placebo effect a physiological response following the administration of an inert "remedy"

  20. referred pain Kandel Fig. 24-5 Purves

  21. Methods for Rainville et al., 1997 To immerse a hand in painfully hot water (47 °C) for 75 sec; Hypnosis: high or low unpleasantness

  22. Activation of anterior cingulate cortex (ACC) by pain PET imaging of human brains Rainville et al 1997

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