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Nucleophilic Substitution: Alkylation of α Carbons

Nucleophilic Substitution: Alkylation of α Carbons. Determining Thermodynamic Enolate. Determining Kinetic Enolate. Polyhalogenation of α Carbons under basic conditions. Formation of Ethers. Williamson ’ s Ether Synthesis. Green Principles Addresses Less Hazardous Reagents Safer Solvent

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Nucleophilic Substitution: Alkylation of α Carbons

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  1. Nucleophilic Substitution:Alkylation of α Carbons

  2. Determining Thermodynamic Enolate

  3. Determining Kinetic Enolate

  4. Polyhalogenation of α Carbons under basic conditions

  5. Formation of Ethers

  6. Williamson’s Ether Synthesis • Green Principles Addresses • Less Hazardous Reagents • Safer Solvent • Use of renewable feedstocks

  7. Intramolecular Williamson EtherSyntheses

  8. Reactions of Epoxides under Neutral and Basic Conditions

  9. Reactions of Epoxides under Neutral and Basic Conditions (cont)

  10. Reactions of Epoxides under Neutral and Basic Conditions (cont)

  11. Reactions of Epoxides under Neutral and Basic Conditions (cont)

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