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Supplemental file 4 Disease free survivals of the entire cohort of patients. 100. 100. Stage I. 80. 80. Stage II. 60. 60. Cumulative Survival (%). Cumulative Survival (%). 40. 40. Stage IV. 20. 20. P = 0.033. 80. 80. 20. 20. 40. 40. 60. 60. 100. 100.

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  1. Supplemental file 4 Disease free survivals of the entire cohort of patients 100 100 Stage I 80 80 Stage II 60 60 Cumulative Survival (%) Cumulative Survival (%) 40 40 Stage IV 20 20 P = 0.033 80 80 20 20 40 40 60 60 100 100 Disease Free Survival (months) Disease Free Survival (months) A Disseminated Nasal P = 0.001 Non-nasal B

  2. 100 100 IPI = 0 P = 0.01 80 80 IPI = 1 IPI = 3 60 60 Cumulative Survival (%) Cumulative Survival (%) Negative EBV DNA SMILE (I) 40 40 IPI = 2 P < 0.001 20 20 Positive EBV DNA SMILE (I) IPI = 5 80 80 20 20 40 40 60 60 100 100 Disease Free Survival (months) Disease Free Survival (months) C D

  3. 100 KIPI = 2 KIPI = 0 80 KIPI = 1 60 Cumulative Survival (%) KIPI = 3 40 20 P = 0.024 KIPI = 4 80 20 40 60 100 Disease Free Survival (months) E

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