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**Purfluorocarbon Enhanced Gas Transport Overview**

Learn about the revolutionary use of Purfluorocarbon in enhancing oxygen transport, treating tissue ischemia, and potential applications in various medical fields. Explore its unique properties and history, including clinical trials, respiratory efficacy in ARDS, and more.

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**Purfluorocarbon Enhanced Gas Transport Overview**

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  1. Purfluorocarbon Enhanced Gas Transport:Overview Bruce D. Spiess, MD, FAHA Professor and Associate Chair for Research Dept. of Anesthesiology

  2. Disclosures: PFC • Research support: Department of Defense- Army combat Casualty, NIH, Office of Naval Research- others.

  3. PFC-Emulsions (and other Preparations) PFC • The only artificial oxygen carrier ever approved in the US by the FDA –Fluosol DA-20% • Treatment of tissue ischemia as an enhanced oxygen diffuser! • Long and Fascinating history of development-Green Cross (Japanese experimentation in Manchuria)

  4. We will examine: PFC • Physiology of Oxygen transport: Hgb based and impediments to O2 delivery. • Fundamentals of why PFC O2 enhanced solubility is different than Hgb O2 transport. • Solubility and enhanced diffusivity make PFC complimentary to Hgb. transport. • Microcirculation! • PFC can deliver O2 with low flow/No FLOW of blood in microcirculation • That is a revolution in Medicine!

  5. We will examine: PFC • Critical O2 delivery- when and how do we salvage tissues? • History of PFCs and early Fluosol work • Orthopedic trials • Cardiac Trials • TBI and Spinal cord work • The Russian experience with Perftoran • US Corporate efforts • Unique future applications

  6. PFC Fundamentally different • PFC should be treated as an ischemia and tissue O2 delivery enhancer- not a “blood substitute”! • PFC can transport NO, and remove N2 • Treatment of air embolism (blast injury), DCS, arterial air embolism (CAGE). • Treatment for CO poisoning • Respiratory efficacy in ARDS. • Others

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