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Purfluorocarbon Enhanced Gas Transport:Overview

Purfluorocarbon Enhanced Gas Transport:Overview. Bruce D. S piess, MD, FAHA Professor and Associate Chair for Research Dept. of Anesthesiology. Disclosures:. PFC. Research support: Department of Defense- Army combat Casualty, NIH, Office of Naval Research- others.

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Purfluorocarbon Enhanced Gas Transport:Overview

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  1. Purfluorocarbon Enhanced Gas Transport:Overview Bruce D. Spiess, MD, FAHA Professor and Associate Chair for Research Dept. of Anesthesiology

  2. Disclosures: PFC • Research support: Department of Defense- Army combat Casualty, NIH, Office of Naval Research- others.

  3. PFC-Emulsions (and other Preparations) PFC • The only artificial oxygen carrier ever approved in the US by the FDA –Fluosol DA-20% • Treatment of tissue ischemia as an enhanced oxygen diffuser! • Long and Fascinating history of development-Green Cross (Japanese experimentation in Manchuria)

  4. We will examine: PFC • Physiology of Oxygen transport: Hgb based and impediments to O2 delivery. • Fundamentals of why PFC O2 enhanced solubility is different than Hgb O2 transport. • Solubility and enhanced diffusivity make PFC complimentary to Hgb. transport. • Microcirculation! • PFC can deliver O2 with low flow/No FLOW of blood in microcirculation • That is a revolution in Medicine!

  5. We will examine: PFC • Critical O2 delivery- when and how do we salvage tissues? • History of PFCs and early Fluosol work • Orthopedic trials • Cardiac Trials • TBI and Spinal cord work • The Russian experience with Perftoran • US Corporate efforts • Unique future applications

  6. PFC Fundamentally different • PFC should be treated as an ischemia and tissue O2 delivery enhancer- not a “blood substitute”! • PFC can transport NO, and remove N2 • Treatment of air embolism (blast injury), DCS, arterial air embolism (CAGE). • Treatment for CO poisoning • Respiratory efficacy in ARDS. • Others

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