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Trans-NIH Research Initiatives Sally A. Amero, Ph.D., OER Harold I. Perl, Ph.D., NIDA Michael A. Sesma, Ph.D., NIMH

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Trans-NIH Research Initiatives Sally A. Amero, Ph.D., OER Harold I. Perl, Ph.D., NIDA Michael A. Sesma, Ph.D., NIMH

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    1. Trans-NIH Research Initiatives Sally A. Amero, Ph.D., OER Harold I. Perl, Ph.D., NIDA Michael A. Sesma, Ph.D., NIMH

    3. NIH Funding Opportunities What is a research initiative? What are they? Solicitations for research in defined areas Where do they come from? Institutes, Centers, and Offices Why does NIH use them? Fill research gaps & create opportunities How are they developed? Collaborative efforts What do they look like? RFA, PA, PAR, PAS Where do you find them? NIH Guide Who to contact? NIH Program Directors

    4. Initiative Process Funding Opportunity Announcements Developed FOAs of mission interest specific to a single IC FOAs of shared interests with other ICs FOAs of shared interests with trans-NIH activities

    5. FOA mechanisms Request for Applications: RFA Institute (or trans-NIH) initiative in defined research area Invitation to submit for a one-time competition Funds are set aside Reviewed by panel for the sponsoring institute No resubmissions

    6. Program Announcements PA, PAS, PAR Solicit grant applications in areas of interest Describe new or expanded interest Re-emphasize a continuing interest May or may not have funds set aside Standard receipt dates – active for 3 years Two revisions allowed Applications reviewed in CSR

    7. Why Trans-NIH Initiatives? Research initiatives relevant to the missions of multiple institutes Research initiatives to develop resources and tools that cross disciplinary boundaries Research initiatives that compel multiple approaches and new methodological perspectives Identify scientific opportunities prime for exploitation or new/renewed focus that promise clear benefits to the scientific community and to the public health Develop an interdisciplinary, creative and adaptable workforce Cross-cutting initiatives that will improve and accelerate biomedical and behavioral research and its impact

    8. Trans-NIH topics Pain Obesity Women’s Health Health Disparities Epigenetics AIDS/HIV Neuroscience Genomics Sleep Disorders Development Pharmacogenetics High Throughput Methods Autism Imaging Bioinformatics Biomarkers Community Based Research Model Organisms Drug Discovery Research Training and still more…..

    9. Who Coordinates Trans-NIH Initiatives? Division of Program Coordination, Planning and Strategic Initiatives (DPCPSI) in the NIH OD Office of Portfolio Analysis and Strategic Initiatives (OPASI): NIH Roadmap Office of Behavioral and Social Sciences Research (OBSSR) Office of Research on Women's Health (ORWH) Office of AIDS Research (OAR) Office of Disease Prevention (ODP)

    11. NIH Roadmap for Medical Research The NIH Roadmap is intended to be an “incubator space” for programs that, due to their cross-cutting relevance and/or complexity, warrant concerted attention from NIH as a whole; to identify major opportunities and gaps in biomedical research that no single institute at NIH could tackle alone but that must be addressed to have the biggest impact on the progress of medical research Major NIH Roadmap Themes New Pathways to Discovery Research Teams of the Future Re-engineering the Clinical Research Enterprise

    12. The 3 Roadmap Themes New Pathways to Discovery: Building Blocks, Pathways, and Networks Molecular Libraries and Imaging Structural Biology Bioinformatics and Computational Biology Nanomedicine Research Teams of the Future High-Risk Research Interdisciplinary Research Public Private Partnerships Re-engineering the Clinical Research Enterprise Clinical Research Networks Clinical outcomes assessment Clinical research training Research policy analysis and coordination Translational research

    13. NIH Roadmap and Common Fund The NIH Reform Act of 2006 established use of a Common Fund to support Trans-NIH Research Roadmap Initiatives must demonstrate: High potential to transform conduct of biomedical and/or behavioral research Synergistic promotion and advancement of the individual missions of the ICs to benefit health Applicability to issues beyond scope of any one or small number of ICs Likelihood that no other entity is able or likely to perform the work A public health benefit of having the results of research in the public domain In FY2008 the NIH Budget included ~$495M to support the NIH Roadmap

    14. Other Trans-NIH Research Initiatives and Programs NIH Blueprint for Neuroscience Research: http://neuroscienceblueprint.nih.gov/ NIH Obesity Research: http://www.obesityresearch.nih.gov/index.htm OBSSR: http://obssr.od.nih.gov/content ORWH: http://orwh.od.nih.gov/index.html OAR: http://www.oar.nih.gov/index.htm ODP: http://odp.od.nih.gov/ BECON: http://www.becon.nih.gov/becon2.htm BISTI: http://www.bisti.nih.gov/

    16. The NIH Neuroscience Blueprint: Develop research tools and infrastructure to serve entire neuroscience community: 14 FOAs in 2006, 2007 Neuroscience Blueprint themes 2006: global-training, genetic resources, neuroimaging tools, core facilities, and tools to enhance the value of clinical research 2007: neurodegeneration 2008: neurodevelopment 2009: neuroplasticity NIH Blueprint funds in FY2008 ~$38M

    17. Developing Trans-NIH Initiatives An Idea generated from NIH Staff, scientists in academia and industry, COPR is chosen for development A Request for Information (RFI) is published in the NIH Guide to seek ideas from the stakeholder community: researchers, health professionals, patient advocates, general public) Approaches may be related to biomedical or behavioral research research resources methods development research training research policies

    19. How New Initiatives are Chosen

    20. Trans-NIH Initiatives Applying for support Use the same strategy as for any other grant application! Identify the FOA’s of interest Contact the Program Staff listed in FOA Be prepared to discuss how your concept addresses the Trans-NIH FOA objectives Inquire about appropriate mechanisms Inquire about scientific review groups for applications in response to the FOA

    21. Application Assignment for Trans-NIH Programs

    22. The NIH Peer Review Process

    23. Review Criteria

    24. The NIH Application and Review Process

    40. Questions?

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