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GEM Design Gel Extrusion Module. Drug is compressed with water swellable Carbopol polymer Tablet is coated with water insoluble CAB coating Laser drill drills uniformly sized holes through coating (~500 m ) Water diffuses into tablet, swells polymer, which extrudes through holes, bringing drug
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GEM DesignGel Extrusion Module • Drug is compressed with water swellable Carbopol polymer • Tablet is coated with water insoluble CAB coating • Laser drill drills uniformly sized holes through coating (~500m) • Water diffuses into tablet, swells polymer, which extrudes through holes, bringing drug • Release rate is controlled by number, size, configuration of holes • Number of holes constrained by surface area, strength of coating