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IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpag

IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm. Immunologic responses. Innate Acquired. Immunologic responses. Innate anatomic physiologic phagocytic inflammatory (acute, not chronic) Acquired …….

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IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpag

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  1. IMMUNOLOGY Bios 328 a textbook-based study of immunology Spring 2003 http://www.lehigh.edu/~sk08/Courses/Bios328/mainpage.htm

  2. Immunologic responses Innate Acquired

  3. Immunologic responses Innate anatomic physiologic phagocytic inflammatory (acute, not chronic) Acquired ……

  4. Innate immunologic response Anatomic: e. g., skin (!) a barrier… sometimes ciliated sometimes coated with mucous sometimes bathed with fluids

  5. Ciliated, coated, bathed… What are the principal routes of entries of pathogens and other noxious agents? Alimentary system Respiratory system Urogenital system Innate immunologic response

  6. Innate immunologic response Ciliated, coated, bathed… Ciliated: sweep entities away or into mucous Coated: entrap entities; expel through coughing Bathed: fluids flush… or serve as solvent for enzymes like lysozyme (which digests the near universal beta 1,4 glycosidic linkage between N-acetylmuramic acid and N-acetyl glucosamine in bacterial walls) Other: fatty acids in skin (affect pH)

  7. Innate immunologic responseviz. physiologic Other: fatty acids in skin (affect pH) More “other”: numerous proteins Interferons Kinins Fibrins Complement

  8. Immunologic response • Skin… obviously “anatomic” • Fluids… phsyiologic (?) • Fatty acids… physiologic again • Phagocytic • Who does this? • Polymorphonuclear leukocytes (aka neutrophils) • Macrophages • Inflammation What is this?

  9. Caldor Rubor Tumor Dolor HEAT REDNESS SWELLING PAIN Inflammation

  10. Immunologic responses Innate Acquired

  11. Immunologic responses Innate also called non-specific Acquired also called specific or adaptive

  12. Immunologic responses Innate Invariant… does not vary with stimulus Acquired Highly variable and has memory

  13. Acquiredimmunologic response Principal features: Specific Able to respond to innumerable stimuli Able to distinguish self and non-self Has memory

  14. Immunology:

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