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Nationwide Prevalence of RA and Penetration of Dmards in Sweden

Neovius M, Simard J & Askling J for the ARTIS Study Group. Nationwide Prevalence of RA and Penetration of Dmards in Sweden. Clinical Epidemiology Unit and Rheumatology Unit Dept of Medicine Karolinska Institutet. Ann Rheum Dis, 2010. Objective.

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Nationwide Prevalence of RA and Penetration of Dmards in Sweden

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  1. Neovius M, Simard J & Askling J for the ARTIS Study Group Nationwide Prevalence of RAand Penetration of Dmardsin Sweden Clinical EpidemiologyUnit and RheumatologyUnit Dept of Medicine Karolinska Institutet Ann Rheum Dis, 2010

  2. Objective To provide nationwide data on the prevalence of RA(including variations by age, sex, geography, demography and education level) and assess anti-rheumatic treatment penetration Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  3. Methods • Patient Identification • Swedish RheumatologyQuality Register • National Patient Register (inpatient & specialist outpatientcare) • Treatment Exposure • PrescribedDrug Register • Swedish Biologics Register ARTIS Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  4. Patient Identification National Patient Register (NPR, 1964-2007; n=57,400) Outpatient: n=48,644 Inpatient: n=32,777 Swedish RheumatologyQuality Register (SRQ, 1995-2007; n=18,201) SRQ & NPR: n=17,499 Prescribed Drug Register (PDR, 2005-2007; n=6,103) ARTIS (1999-2007; n=8,155) PDR & SRQ: n=5,801 PDR & NPR: n=5,947 ARTIS & SRQ: n=8,155ARTIS & PDR: n=5,750 ARTIS & NPR: n=7,965 Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  5. Results

  6. Prevalence of RA by Sex & AgeJan 1, 2008 (n=58,102) Cases defined as ever having a visit in inpatient or outpatient specialist care with a diagnosis of rheumatoid arthritis, or a listing in the Swedish Rheumatology Quality Register Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  7. Using Different Case Definitions Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  8. Using Different Case Definitions By Sex Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  9. Prevalence by Place of Residence Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  10. Prevalence by Place of Residence Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  11. Prevalence by Place of Residence Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  12. Prevalence by County (n=58,102) Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  13. Prevalence by Education Level and Age (n=39,551) No population statistics on education level for persons ≥75y16-29y old persons excluded as many may not have completed their education Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  14. Comparison of prevalence estimates in the current study (Sweden 2008) with a previous Swedish study by Simonsson et al (Sweden 1995)[3], a Norwegian study by Kvien et al (Norway 1994)[2], and an American study by Gabriel et al (Rochester 1985)[7] after applying the age-cutoffs used in the respective studies Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  15. penetration of biologic and non-biologicdmardS

  16. Biologics Penetration by Age Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  17. Biologics Penetration by Age Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  18. DMARD Penetration by AgeNon-Biologic Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  19. DMARD Penetration by AgeNon-Biologic Neovius, Simard & Askling for the ARTIS Study Group, ARD 2010

  20. References • Neovius M, Simard J, Askling J for the ARTIS Study GroupNationwide Prevalence of RheumatoidArthritis and Penetration of Disease-ModifyingDrugs in SwedenAnn Rheum Dis 2010 • Neovius M, Simard J, Sundström A, Jacobsson L, Geborek P, Saxne T, Klareskog L & Askling J for the ARTIS Study GroupGeneralisability of Clinical Registers used for DrugSafety and ComparativeEffectiveness Research: Coverage of the Swedish Biologics RegisterAnn Rheum Dis 2010 • Simard J, Arkema E, Sundström A, Geborek P, Saxne T, Baecklund E, Coster L, Dackhammar C, Jacobsson L, Rütting M, Lindblad S, Rantapää-Dahlqvist S, Klareskog L, Van Vollenhoven RF, Neovius M & Askling JTen years with biologics: For whomdo data on effectiveness and long-termsafetyapply? Rheumatology2010 • Askling J, Fored CM, Geborek P, Jacobsson LT, van Vollenhoven R, Feltelius N, Lindblad S & Klareskog LSwedish registers to examinedrugsafety and clinicalissues in RA. Ann Rheum Dis 2006;65(6):707-12. • Neovius M, Sundstrom A, Simard J, Wettermark B, Cars T, Feltelius N, Askling J & Klareskog L for the ARTIS Study GroupSmall-area variations in sales of TNF inhibitors in Sweden between 2000 and 2009Scand J Rheumatol 2010

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