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Updated Search of Medline, EMBASE, regulatory documents and trial registries (n=280)

Updated Search of Medline, EMBASE, regulatory documents and trial registries (n=280). Excluded on basis of title and abstract for clearly not fulfilling inclusion criteria on basis of intervention, population or duration of study (n= 222).

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Updated Search of Medline, EMBASE, regulatory documents and trial registries (n=280)

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  1. Updated Search of Medline, EMBASE, regulatory documents and trial registries (n=280) Excluded on basis of title and abstract for clearly not fulfilling inclusion criteria on basis of intervention, population or duration of study (n= 222) Further full text review of potentially relevant articles(n=58) 38 long term RCTs of TZDs from prior Systematic Reviews Potentially relevant randomized controlled datasets of at least 52 weeks duration (n=43) 33 trials excluded because (n=24), no details on Pneumonia (n=5) studies- conditions other than diabetes or choice of comparator not relevant (n=4) troglitazone trials Dataset included in the review of pneumonia ( n=10 datasets reporting on 13 Long term RCTs) Figure 1: Flowchart describing study selection for Long Term RCTs reporting on Pneumonia/Lowe Respiratory Tract Infections 53 full text studies excluded because (n=33) duration less than 52 weeks (n=8) Not RCT (n= 12) Population or comparator treatment not relevant Potentially relevant randomized controlled datasets of at least 52 weeks duration (n=5)

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