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Medical Imaging Resource Center (MIRC) Clinical Trial Applications Joshua Tan

Medical Imaging Resource Center (MIRC) Clinical Trial Applications Joshua Tan Division of Radiologic Sciences Wake Forest University School of Medicine Departments of Radiology and Biomedical Engineering November 28, 2005 - RSNA 2005 Chicago, IL. Overview. Introduction

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Medical Imaging Resource Center (MIRC) Clinical Trial Applications Joshua Tan

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  1. Medical Imaging Resource Center (MIRC) Clinical Trial Applications Joshua Tan Division of Radiologic Sciences Wake Forest University School of Medicine Departments of Radiology and Biomedical Engineering November 28, 2005 - RSNA 2005 Chicago, IL

  2. Overview • Introduction • WFUSM MIRC configuration • WFUSM uses MIRC for multi-center clinical trials

  3. Introduction • MIRC collaboration among RSNA, UPenn, and WFUSM was initiated in early 2004. • UPenn and WFUSM MIRC test (WAKEUP) • Images sent from WFUSM research MR scanner to WFUSM MIRC to UPenn MIRC • RSNA • Chris Carr • John Perry • WFUSM • Dr. Jeffrey Carr • Dr. Kerry Link • Dr. Joseph Maldjian • Dr. Peter Santago • Bob Ellison • Joshua Tan • UPenn • Dr. Nick Bryan • Lisa Desiderio • Dengfeng Liu

  4. WFUSM Center for Biomolecular Imaging Dedicated research modalities GE Twin Speed 1.5T MR Scanner GE Sigma Excite 3.0T MR Scanner GE 16-slice Light Speed Pro CT Scanner GE Discovery ST-8 PET/CT Scanner GE Advance NXi PET Scanner Concord MicroPET Scanner Bruker 7.0T MicroMR Scanner with a 30cm. bore

  5. WFUSM Firewall TeraRecon imaging analysis workstation GE Advantage imaging analysis workstation Internet Remote MIRC FieldCenter WFUSM MIRC in DMZ Remote Network WFUSM Network Internet External RAID backup system MIRC within WFUSM firewall External Ultra SCSI3 WFUSM research DICOM server WFUSM NAS WFUSM MIRC hardware configuration Remote MR Remote CT

  6. External RAID backup system WFUSM research DICOM server • Research DICOM server WFUSM NAS WFUSM Network Remote Network Internet Remote MIRC FieldCenter WFUSM MIRC WFUSM MIRC software configuration • MIRC computer • MIRC FieldCenter or MIRC v T26 • Tomcat v 4.1.29 • Java J2SE v 1.4.2_10 SDK Remote CT Remote MR

  7. WFUSM research DICOM server Titan: 192.168.1.110: port 104 • External RAID storage • 8 x 250GB hard drives • Ultra SCSI-3 • Raid5 configuration • ~1.7TB of usable space • Dell PowerEdge 2800 server • Dual 3.0GHz Intel Xeon CPUs • 1GB ECC DDR ram • 3 x 73GB Ultra 320 SCSI hard drives • in a RAID5 configuration • Gigabit Network Interface Card • Software on PowerEdge • Red Hat Linux • Version 9.0 • WS 3.0 • MySQL Database • Mallinckrodt CTN software • PHP • HTML and XML Application Entity Titles WFUSM Network • WHIMS • CARDIA_XX • CARDIA_XV • CARDIA_PILOT • CARDIA_QC • WHI • WHI_PILOT • WHI_QC • CAMPS • ADNI • CIREN WFUSM NAS

  8. Required DICOM elements for CTN DICOM server (0008, 0018) SOP Instance UID (0008, 0020) Study Date (0008, 0030) Study Time (0008, 0050) Accession Number (0008, 0060) Modality (0008, 0090) Referring Physician Name (0010, 0010) Patient Name(0010, 0020) Patient ID(0010, 0030) Birthdate(0010, 0040) Sex (0020, 000D) Study Instance UID (0020, 000E) Series Instance UID(0020, 0010) Study ID (0020, 0011) Series Number(0020, 0013) Instance Number(0028, 0002) Samples Per Pixel(0028, 0010) Rows (0028, 0011) Columns(0028, 0101) Bits Stored (0028, 0103) Pixel Representation DICOM element must have a value

  9. Exabyte VXA-2 Autoloader (1 x 10) • NAS (network attached storage) • EMC • Fiber attached • Raid5+1 configuration WFUSM NAS Sony external DL/DVD±RW drive • Research archiving server • VXA-2 Tape (80/160GB) • DVD-R (4.7/8.5GB) WFUSM research archiving server WFUSM DICOM research images Long term storage and archiving • External attached RAID • Ultra SCSI-3 • Raid5 configuration WFUSM MIRC receivers External RAID backup system WFUSM Network WFUSM research DICOM server

  10. WFUSM Firewall WFUSM research DICOM server Remote MIRC FieldCenter Internet WFUSM MIRC in DMZ Remote Network WFUSM Network Internet MIRC within WFUSM firewall WFUSM MIRC DMZ and B2B VPN connections • DMZ (demilitarized zone) • Ports 8080, 8443 (internet) • Open on WFUSM MIRC to receive via MIRC software • Port 104 (intranet) • Only open to the internal WFUSM network on port 104 to DICOM export to WFUSM DICOM research server • NAT (network address translation) • B2B VPN (branch to branch virtual private network) • Remote modality can DICOM export directly to WFUSM MIRC • Information Services from both locations must collaborate for configuration to properly connect and transfer DICOM images Remote CT Remote MR

  11. MIRC software tools • FieldCenter • Application to receive DICOM images from an imaging modality • DICOM export images from remote sites to reading center via internet • Anonymize/de-identify/modify DICOM images • DicomEditor • Modification and correction of DICOM header • Powerful anonymization/de-identification tool • Batch modifying application • FileSender • DICOM export corrected images back to workstation/DICOM server • DICOM export images from local media and network drives • MOD • CD-rom/DVD-rom • Hard drive • Other misc media formats

  12. Clinical trials using MIRC • WHIMS • Women's Health Initiative Memory Study • Import DICOM images • CARDIA Year20 • Coronary Artery Risk Development in Young Adults • Import DICOM images • WHI • Women's Health Initiative • Import DICOM images • CAMPS • Carotid Atherosclerosis MRI Progression • Export DICOM images • ADNI • Alzheimer's Disease Neuroimaging Initiative • Export DICOM images to a pc • CIREN (WFUSM internal) • Crash Injury Research and Engineering Network • Archive and distribute DICOM images

  13. Remote Network Internet Calcium scoring workstations Remote MIRC FieldCenter WFUSM firewall #1 Internet WFUSM firewall #1 MIRC within WFUSM firewall RAID storage WFUSM firewall #2 WFUSM MIRC in DMZ WFUSM DICOM research server CARDIA year20 data flow UIC CT USF CT UAB CT UMN CT

  14. Internet Remote Network Remote Network WFUSM firewall #1 Remote MIRC FieldCenter HTTP import to DICOM export (MIRC IN to Titan) HTTP import on http://182.158.1.101:8443/CARDIA_WFU/import/doc DICOM export from CARDIA_WFU@192.158.1.101:3333 to CARDIA_XX (Titan) MIRC software WFUSM firewall #2 RAID storage WFUSM MIRC in DMZ MIRC IN: 182.158.1.101: port 8443 (ext) 192.158.1.101: port 104,3333,8443 (int) WFUSM DICOM research server Titan: 192.168.1.110: port 104 AE TITLE: CARDIA_XX CARDIA year20 data flow UIC/USF to DMZ WFUSM MIRC UIC CT USF CT

  15. Internet DICOM export WFUSM firewall #1 DICOM import to HTTP export (CT Scanner to Delta) DICOM import from CT Scanner to CARDIA_UAB@192.168.1.101:3333 (Delta) DICOM import from CT Scanner to CARDIA_UMN@192.168.1.101:3334 (Delta) HTTP export to http://192.168.1.101:8443/car_uab/import/doc HTTP export to http://192.168.1.101:8443/car_umn/import/doc MIRC software HTTP import to DICOM export (Delta to Titan) HTTP import on http://192.168.1.101:8443/car_uab/import/doc HTTP import on http://192.168.1.101:8443/car_umn/import/doc DICOM export from CAR_UAB@192.168.1.101:3335 to CARDIA_XX (Titan) DICOM export from CAR_UMN@192.168.1.101:3336 to CARDIA_XX (Titan) MIRC software RAID storage WFUSM DICOM research server Titan: 192.168.1.110: port 104 AE TITLE: CARDIA_XX MIRC within WFUSM firewall Delta: 192.168.1.101 ports 104,3333,3334,3335,3336,8443 CARDIA year20 data flow UAB/UMN Branch to Branch VPN to WFUSM UAB CT UMN CT

  16. Remote Network FileSender Loaded on WFUSM MIRC receiver Calcium scoring workstations Remote MIRC FieldCenter Internet WFUSM firewall #1 WFUSM MIRC receiver RAID storage WFUSM firewall #2 WFUSM DICOM research server WFUSM MIRC in DMZ WHI data flow UIC USF UPMC UMN CDs sent via from 26 Field Centers

  17. Remote Network Internet Remote Network Remote Network WFUSM FIREWALL #1 Remote MIRC FieldCenter Remote Network HTTP import to DICOM export (MIRC IN to Titan) HTTP import on http://182.158.1.101:8443/WHI/import/doc DICOM export from WHI@192.158.1.101:3334 to WHI (Titan) MIRC software WFUSM FIREWALL #2 RAID storage WFUSM MIRC in DMZ MIRC IN: 182.158.1.101: port 8443 (ext) 192.158.1.101: port 104,3334,8443 (int) WFUSM DICOM research server Titan: 192.168.1.110: port 104 AE TITLE: WHI WHI fieldcenter data flow UAB/UIC/UMN/UPMC/USF to DMZ WFUSM MIRC UIC CT UMN CT UPMC CT USF CT

  18. FileSender WFUSM Network DICOM import to HTTP export (CD to Delta) DICOM import from CD to WHI_UPLOAD@192.168.1.101:3337 (Delta) HTTP export to http://192.168.1.101:8443/WHI_EXPORT/import/doc MIRC software HTTP import to DICOM export (Delta to Titan) HTTP import on http://192.168.1.101:8443/WHI_EXPORT/import/doc DICOM export from WHI_EXPORT@192.168.1.101:3338 to WHI (Titan) MIRC software RAID storage WFUSM DICOM research server Titan: 192.168.1.110: port 104 AE TITLE: WHI MIRC with WFUSM firewall Delta: 192.168.1.101: ports 104,3337,3338,8443 WHI data flow CD/DICOM EXPORT to WFUSM RECEIVER CDs sent via from 26 Field Centers to WFUSM

  19. HTTP export DICOM send WFUSM Network Internet WFUSM MIRC OUT CAMPS MIRC University of Washington ADNI website UCLA CIREN WFUSM (internal) CAMPS/ADNI/CIREN data flow WFUSM modality to WFUSM MIRC OUT WFUSM CT WFUSM MR

  20. MIRC software summary • Secure DICOM image transfer via the Internet • Stable • Open-source • Multi-faceted and versatile • De-identification and modification features • Technicians “love” to use the MIRC software • Easy to configure and use • Web-based interface for effortless examination of received images

  21. Questions or comments?

  22. Special Thanks to: John Perry (RSNA) Peter Santago, Ph.D. (WFUSM) J. Jeffrey Carr, M.D., M.S. (WFUSM) Kerry M. Link, M.D. (WFUSM) Bob Ellison (WFUSM) Nick Bryan, M.D., Ph.D. (UPenn) Lisa Desiderio (UPenn) DengFeng Liu (UPenn) Steve Moore (Mallinckrodt) Acknowledgements: Wake Forest University School of Medicine (Radiology and Biomedical Engineering) Wake Forest University Health Sciences University of Pennsylvania Winston-Salem State University

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