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Pharmacy 324 Dr. Piquette-Miller Professor, Leslie Dan Faculty of Pharmacy

Pharmacy 324 Dr. Piquette-Miller Professor, Leslie Dan Faculty of Pharmacy Room 1003, Pharmacy Building Phone: 416-946-3057 m.piquette.miller@utoronto.ca. Background: BSc Pharmacy U of A Pharmacist Alberta PhD Pharmacokinetics U of A

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Pharmacy 324 Dr. Piquette-Miller Professor, Leslie Dan Faculty of Pharmacy

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  1. Pharmacy 324 Dr. Piquette-Miller Professor, Leslie Dan Faculty of Pharmacy Room 1003, Pharmacy Building Phone: 416-946-3057 m.piquette.miller@utoronto.ca

  2. Background: BSc Pharmacy U of A Pharmacist Alberta PhD Pharmacokinetics U of A Post-Doc PK & Mol. Pharm. UCSF Current Professional involvement: Associate Editor: Clinical Pharmacology & Therapeutics President: Canadian Society of Clinical Pharmacology

  3. Research • Understanding Individual Variability in Drug Disposition and Response • Drug-disease Interactions • Contribution of ABC Drug Efflux Transporters • Improving Tumor responsiveness to Anticancer Agents • Drug Resistance • Dosing and Drug Delivery Strategies

  4. Teaching Assistant Mr.Sarabjit Gahir, BSc. Pharm (2004) PhD candidate Room 1040 LDFB 416-946-3154 Email: sarabjit.gahir@gmail.com

  5. Introduction to 2nd term of PHM 324 • Course goals • Lecture schedule • Office hours • Email policy • Assignments & Exam • Marks & Format • How you can do well in the course

  6. In this term we will build upon the fundamental PK concepts taught in the 1st term in order to understand, describe and predict the pharmacokinetics of drugs in clinical settings comprised of different patient population groups. “If it were not for the great variability among individuals, medicine might as well be a science and not an art.” Sir William Osler, 1892

  7. Goal of 2nd Term: PERSONALIZED MEDICINE: Delivery of the right drug to the right patient at the right dose Objectives: 1) To develop competence in adjusting drug and dosage regimens for patients based on individual patient factors and what is known about the pharmacokinetics of that drug. 2) To develop strategies to enable incorporation of “drug & dosage individualization” in a busy clinical setting.

  8. Lectures Mondays 9-10 am PB B250 Thursdays 2-3 pm PB B150 2-3 tutorials will be organized based on your schedule.

  9. Lecture Schedule: Jan 10: Clearance Concepts Revisited Jan 14 Environmental Factors in Variable Drug Response Jan 17, 21 Pharmacogenetic Factors in Variable Drug Response Jan 24-31 Hepatic CL & Dose adjustment based on Hepatic Function Feb 4, 7 :Renal CL &Dose adjustment based onRenal Function Feb 11, 14: Dosage Adjustment in Special Populations Feb 18, 21: Reading Week Assignment # 1 handed out by Feb 15 Feb 25, 28:Protein Binding Concepts Mar 3, 6: Pharmacodynamics Dr. Shirley Teng Mar 10-20: Therapeutic Drug Monitoring & Clinical PK Mar 27: Pain Week (No class). Assign. # 2: Case Study Pain Management Mar 31- Apr 7: Nonlinear PK & Therapeutic Monitoring Apr 10: Review

  10. An additional tutorial can be scheduled in April (coordinated with class schedule) to assist in preparation for final exam. Class requests for tutorials on specific subjects can be arranged.

  11. Note: • Several changes in lecture material since last year. • Exams and assignments will reflect what is covered in lectures and assigned readings for this year.

  12. Lecture Materials • Hardcopy of each lecture will be provided to students in advance of class. Space provided next to each slide for notes. • Lecture notes will also be provided on website prior to final exam.

  13. Textbook: • Applied Biopharmaceuticals & Pharmacokinetics 5th Edition • L. Shargel S. Wu-Pong & A. Yu • Highly recommend reading relevant sections. • Readings: • Will post several review articles on website. Student comment (06): “the textbook readings should really be required”

  14. Assignments • There will be 2 assignments, each worth 7.5% of the final mark. • Each assignment should take 4-6 hrs to complete. Students will have at least 2 weeks to complete assignments.

  15. Final Exam • Worth 35% of final mark • Exam format will be mix of calculations (show your work), short answer and multiple choice. • While exam will be based on material from this term, students must know essential PK calculations/ concepts from last term. • I will discuss what I consider essential concepts in my lectures.

  16. How to do well in the course 1. Attend class 2. Do practice problems (from class, old exams, textbooks) and assignments to ensure you understand how to do the calculations. 3. Review relevant sections in textbook. 4. Do your own assignments.

  17. Office Hours Mondays 3-4 pm Will be out of country: March 3rd- 10th

  18. Email Policy • Emails must have subject line and should be from a U of T address. • If the question can not be adequately answered with a brief response, I will request that the student arrange for a meeting with me or the TA in person. • In order to ensure fairness among students, Email questions and answers maybe posted on website or distributed to class via email. • Will respond to emails during regular working hours (not on weekends or evenings) and response times may vary.

  19. Helpful Websites for overview of concepts and practice problems http://www.pharmacy.ualberta.ca/pharm415/contents.htm http://www.uiowa.edu/~c046138/138tutorialindex.htm http://www.boomer.org/c/p2/syllabus.html

  20. Curriculum Changes • Volunteers to assist in developing new outline for the Pharmacokinetics/ Personalized Medicine Course?

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