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Advanced PubMed searching. Marisa Conte meese@umich.edu. Topics. Clinical queries and other tools Search construction: controlled vocabulary and Boolean searching Advanced search and limits Managing results: export citations, save searches and collections, customize retrieval. Tour.
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Advanced PubMedsearching Marisa Conte meese@umich.edu
Topics • Clinical queries and other tools • Search construction: controlled vocabulary and Boolean searching • Advanced search and limits • Managing results: export citations, save searches and collections, customize retrieval
Search construction • Identify relevant concepts, including controlled vocabulary • Combine concepts w/ appropriate Boolean logic • Use special features or limits to refine results
Identifying concepts Medical Subject Headings (MeSH)
Search construction: Concept building • Identify major concepts • Identify preferred terms for concepts (including subheadings if relevant) • Identify synonyms for major concepts
Review: Keywords vs. controlled vocabulary Keywords Controlled vocabularies
Search construction: Vocabulary Keywords Controlled vocabularies • What are they? • Literal search • Looks for occurrences of words • When to use? • Current topics • Difficult-to-describe concepts • No vocabulary exists in database • Examples • Drug names (Lipitor, Prozac) • Slang • Concepts (Swine flu, oil spill)
Search construction: Vocabulary Keywords Controlled vocabularies • What are they? • Set of words or phrases used to describe concepts • Dictionary of accepted terms for a database • When to use? • Searching a database that uses one • Examples • MeSH (Medical Subject Headings) • EMTREE (Embase)
Shortcuts to MeSH • ‘Search details’ from results screen • View MeSH indexing from relevant citations • Use Advanced search > ‘Search builder’ feature with MeSH dropdown selected
MeSH database • Identify MeSH headings • Entry terms can suggest keywords for comprehensive searches • Hierarchy view can help identify more relevant (broader/more focused) terms • Subheadings can help refine search • Focus on specific application of MeSH: eg bronchiolitis/drug therapy • Search builder exports MeSH term to PubMed
Question 1: • Does Epstein Barr virus cause a chronic hepatitis, in particular one that resembles autoimmune hepatitis? • Try: keyword search • Try: Clinical queries, using etiology as a filter • Try: MeSH (+/- keywords) • Epstein-Barr virus infections [mh] AND hepatitis, autoimmune [mh]
Review: Boolean Logic Concept 1 Child Children Adolescent Teenager Concept 2 Obesity Obese Overweight BMI Concept 3 Mortality Premature death OR OR OR AND AND OR OR OR OR
Combining concepts - searchline • Use parentheses to group related concepts • Capitalize Boolean operators
Question 2 • What are the cytologic features that distinguish a high grade intraductal pancreatic mucinous neoplasm (IPMN) from a low grade neoplasm? • Identify key terms: intraductal papillary mucinous neoplasm [tiab]; carcinoma, pancreatic ductal [mh]; cytodiagnosis [mh]; cytology [tiab] OR cytologic [tiab] • Combine concepts
What do I do when I get … Too many results? Not enough results? Remove limits Add keywords or MeSH terms to improve recall Use related citations to identify other relevant concepts • Use MeSH and/or subheadings to refine concept definition • Restrict keywords to title and/or abstract • Use limits – date, publication type, etc. • Use special features – clinical queries or topic-specific queries
Search construction: Techniques • Limits – use sparingly (language, age, publication type)
managing results MyNCBI
Set up account • Click myNCBI in upper right corner • Click ‘Register for an account’ • Complete registration screen (including email address) • Confirm email sent to account
Manage results Email, export to EndNote, save as Collection
Save search, set search alerts Save search URL, save search to MyNCBI
Set preferences and filters Customize PubMed
Questions? meese@umich.edu