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Searching for Drug Information In PubMed

Searching for Drug Information In PubMed. PubMed for Trainers Spring 2014 U.S. National Library of Medicine (NLM) and NLM Training Center. Goal: To gain familiarity with the NLM MeSH vocabulary related to chemicals and drugs and to get comfortable with searching for drug information in PubMed. .

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Searching for Drug Information In PubMed

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  1. Searching for Drug Information In PubMed PubMed for Trainers Spring 2014U.S. National Library of Medicine (NLM) and NLM Training Center

  2. Goal: To gain familiarity with the NLM MeSH vocabulary related to chemicals and drugs and to get comfortable with searching for drug information in PubMed. PubMed for Trainers

  3. Objectives: By the end of this session you will be able to: • Explain how chemicals, drugs and other substances are described in MeSH. • Search for drugs or chemicals in PubMed. • Search using pharmacological action terms. PubMed for Trainers

  4. Help, I’m not a Chemist! PubMed for Trainers

  5. Drugs and Chemicals in MeSH PubMed for Trainers

  6. Many Synonyms, One Preferred Name, Same Concept PubMed for Trainers

  7. Common v. Chemical Names • Mimosine • 3-Hydroxy-4-oxo-1(4H) pyridinealanine • C8H10N2O4 • Aspirin • Acetylsalicylic Acid • Always exceptions … 1,2-dinitrobenzene • Look at the Drug Handout PubMed for Trainers

  8. Exercise: Preferred Term Develop a good PubMed search for information on Zantac. PubMed for Trainers

  9. The Chemicals and Drugs Category in MeSH • Inorganic Chemicals • Organic Chemicals • Heterocyclic Compounds • Polycyclic Compounds • Macromolecular Substances • Hormones, Hormone Substitutes, and Hormone Antagonists • Enzymes and Coenzymes • Carbohydrates • Lipids • Amino Acids, Peptides, and Proteins • Nucleic Acids, Nucleotides, and Nucleosides • Complex Mixtures • Biological Factors • Biomedical and Dental Materials • Pharmaceutical Preparations • Chemical Actions and Uses

  10. Medical Subject Headings (MeSH® Vocabulary) PubMed for Trainers

  11. Supplementary Concepts PubMed for Trainers

  12. Supplementary Concepts (cont.) PubMed for Trainers

  13. Supplementary Concepts (cont.) PubMed for Trainers

  14. Mapped to MeSH Dibenzazepines/pharmacokinetics AND metapramine PubMed for Trainers

  15. MeSH Heading v. SCRs: Why Both? MeSH Headings Supplementary Concepts Located in hierarchy Subheadings Updated annually Pharmacologic Actions Entry Terms Not located in hierarchy no explosion No subheadings Updated weekly Pharmacologic Actions Entry Terms Heading Mapped To Can become MeSH Heading PubMed for Trainers

  16. SCRs Are… • Updated Weekly Update SCR’s PubMed for Trainers

  17. SCRs Do Not… • Take Subheadings PubMed for Trainers

  18. SCRs Are Not… • In the MeSH Hierarchy. No explosion! PubMed for Trainers

  19. Exercise: Headings, Subheadings and Supplementary Concepts What MeSH Heading/Subheading combination would be applied to a citation for an article about the synthesis of sordarin? What search would retrieve only highly relevant citations on this topic? PubMed for Trainers

  20. Searching Tip: Use Tags Sparingly • Use [mh] for drugs that you know are MeSH Headings: • oseltamivir [mh] • dibenzazepines [mh] • You can use [nm] for drugs that are Supplementary Concepts OR MeSH Headings: • metapramine [nm] • dibenzazepines [nm] • water [nm] • BUT headings will not explode if searched with [nm]. PubMed for Trainers

  21. Best way to search for a drug: No tags PubMed for Trainers

  22. Pharmacological Action Terms http://www.sciencephoto.com/media/282094/enlarge The way a chemical or drug behaves in the body PubMed for Trainers

  23. Pharmacological action terms PubMed for Trainers

  24. PubMed for Trainers

  25. Pharmacological Action Terms PubMed for Trainers

  26. The MeSH Heading Record PubMed for Trainers

  27. Drug AND MeSH Heading PubMed for Trainers

  28. Pharmacological Action Record PubMed for Trainers

  29. MeSH Record vs. PA Record • MeSH Record: • A concept / topic • PA record: • A tool (list of drugs with that PA) PubMed for Trainers

  30. Disease AND Pharmacological Action [pa] PubMed for Trainers

  31. PubMed for Trainers

  32. Review – 2 Ways to Use PAs 1. Drug AND Pharmacological Action – tagged [mh] • Example: • lithium carbonate AND antidepressive agents [mh] • retrieves articles about lithium carbonate as an antidepressive agent. 2. Disease AND Pharmacological Action – tagged [pa] • Example: • panic disorder AND antidepressive agents [pa] • retrieves articles about any antidepressive chemical or drug and panic disorder. PubMed for Trainers

  33. Teachback • In groups of 2 or 3, explain to each other when and why you would use the [mh] or [pa] tags to search for pharmacologic actions with a drug or disease. • Use these examples: • Find articles about Bismuth or Magnesium Hydroxide used as antacids. • Find articles about treating GERD or Heartburn with antacids. PubMed for Trainers

  34. Exercise: Pharmacological Actions Recently there has been some interest in thalidomide as an angiogenesis inhibitor. How might you search to find relevant records? PubMed for Trainers

  35. Summary You should now be able to: • Explain how chemicals, drugs and other substances are described in MeSH. • Search for drugs or chemicals in PubMed. • Search using pharmacological action terms. PubMed for Trainers

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