Embase Find quick, relevant answers to your biomedical questions

1. Embase Find quick, relevant answers to your biomedical questions

2. Section 1. Review / Confirm understanding of your research needs

3. Section 1. Your challenges & Research Needs • Conduct systematic reviews of the literature • Set up complex search strategies and alerts for stakeholders and departments • Search Medline and Embase together • Set up and distribute alerts relating to evidence-based medicine • Access the most up to date information related to a disease that you are tracking • Make sure that all relevant information is disseminated throughout the organization • Monitor and track all adverse events for early and complete detection of any and all adverse effects (signaling) • Make sure you respond to your internal stakeholder’s request in a timely manner

4. Section 2. Evidence Based Medicine / Systematic Searching

5. Section 2. “How do you know if one treatment will work better than another, or if it will do more harm than good?” Cochrane Reviews are systematic reviews of primary research in human health care and health policy, and are internationally recognized as the highest standard in evidence-based health care. They investigate the effects of interventions for prevention, treatment and rehabilitation. They also assess the accuracy of a diagnostic test for a given condition in a specific patient group and setting. They are published online in The Cochrane Library.

6. Section 2. “How do you know if one treatment will work better than another, or if it will do more harm than good?” Each systematic review addresses a clearly formulated question. For example: Can antibiotics help in alleviating the symptoms of a sore throat?  All the existing primary research on a topic that meets certain criteria is searched for and collated, and then assessed using stringent guidelines, to establish whether or not there is conclusive evidence about a specific treatment. The reviews are updated regularly, ensuring that treatment decisions can be based on the most up-to-date and reliable evidence.

7. Section 2. Case Study: Embase & Evidence Based Medicine A real example of the high risks of NOT using Embase

8. Section 2. Medicine Without Evidence Johns Hopkins’ Tragedy: Could Librarians Have Prevented a Death? Source: http://newsbreaks.infotoday.com/nbreader.asp?ArticleID=17534

9. Section 2.

10. Section 2.

11. Section 2. EBM Terms in Embase / Emtree • via Advanced Limits in Advanced Search • via Emtree

12. Section 3. What is Embase and How it Supports Academic Institutions

13. Section 3. What is Embase? Embase is the world’s most comprehensive, intelligent biomedical research tool, providing the drug and drug-related research community with reliable and authoritative content, to advance new biomedical and pharmaceutical discovery. Confidence Find all relevant articles that may not otherwise be found by alternative databases Deep Biomedical Indexing All relevant, up-to-date, biomedical information from the research literature Precise Retrieval Deep and focused research through powerful retrieval tools

14. Section 3. How Embase Delivers Value… We make sure you don’t miss any biomedical literature ...by including literature and information resources in a timely manner Conference proceedings Scientific Journals In Press (unpublished) ...by reading full-text to identify drugs, diseases, adverse affects, clinical trials, drug trade names etc. Deep indexing using own taxonomy (EMTREE) They only close alternative is readingall the articles ...by enabling advanced search filters to drill down a comprehensive search to a relevant and manageable record set Very powerful Search Environment Good precision and recall balance ...by allowing users to automate searching and result management Automation and documentation

15. Section 3.1 Content

16. Section 3.1 Content Overview Emtree: Biomedical thesaurus, over 60k terms Embase: Fully indexed: Over 7,700 journals (including MEDLINE), 1950- MEDLINE: 2,500 journals unique to Embase, mapped to Embaseindexing, 1950- (including MEDLINE Classic) AIP and In Process: Indexing added, from 2009 Embase Classic: Digitally scanned and re-indexed, 1947-1973 Conference Abstracts: Indexing added, from 2009 1947 1950 1974 2009 And counting… 2,700 records added per day 1,000,000 records added per year

17. Section 3.1 Embase Scope & Coverage (2012) Pharmacology & Taxicology 12% General Clinical Medicine 11% Genetics, Biochemistry & Molecular Biology 10% Neurology & Behavioral Medicine 8% Microbiology & Infectious Disease 7% Cardiology & Hematology 6% Psychiatry & Mental Health 6% Oncology 5% Healthcare Policy & Management 4% Allergy & Immunology 4% Pediatrics 4% Endocrinology & Metabolism 3% Obstetrics & Gynecology 3% Biomedical Engineering & Medical Devices 3% Anesthesiology & Intensive Care 3% Gastroenterology 2% Respiratory Medicine 2% Nephrology & Urology 2% Dermatology 2% Other topics 28% Including public health, basic biomedical science and topics included from MEDLINE

18. Section 3.1 Embasevs MEDLINE – Scope Similar overall pattern of coverage... but with two major differences 1. Pharmacology & toxicology Embase: 11.2% (889 titles)MEDLINE: 8.3% (465 titles) 2. General clinical medicine Embase: 10.5% (835 titles)MEDLINE: 8.9% (495 titles)

19. Section 3.1 Embasevs MEDLINE – Searching the Difference

20. Section 3.1 Embase Records

21. Section 3.1 Embase Records Medline on PubMed 1.0 m 800 K 600 K 400 K 200 K 01 02 03 04 05 06 07 08 09 10 11

22. Section 3.1 Embase (Active) Journals in 2012 Embase: now covers 7960 journals (20 March 2012) Indexed at Embase (5396 titles) Indexed by MEDLINE (e.g on PubMed) (5592 titles) 3028 journals Indexed at EmbaseAlso covered by MEDLINE Search:[embase]/lim AND [medline]/lim 2564 journals Indexed by MEDLINEAlso in MEDLINE Search:[medline]/lim NOT [embase]/lim 2368 journals Indexed at EmbaseUnique to Embase Search:[embase]/lim

23. Section 3.1 Journal Articles Conference Abstracts 1.0 m 800 K 600 K 400 K 200 K 01 02 03 04 05 06 07 08 09 10 11

24. Section 3.2 Indexing (Emtree Thesaurus)

25. Section 3.2 Deep Indexing – EMTREE • Emtree is a Life Science Thesaurus. A controlled vocabulary for Biomedicine and related Life Sciences • Easy to Search Over 60,000 preferred terms and more than 270,000 synonyms • Comprehensive Drug Searching • Chemical names, trade names, laboratory/research codes, and more than 28,000 generic drugs and chemicals (FDA, EMEA and WHO) • Up-To-Date The latest drugs, diseases, organisms and procedures are indexed and added annually • Inclusive Terminology All MeSH terms, with links to more than 20,000 CAS registry number

26. Section 3.2 Deep Indexing – EMTREE 60K terms (>260,000 synonyms) and all MeSH terms 29K drug and chemical terms Emtree updated 3 times a year (back-posting each time) All drug generic names described by FDA and EMA, all International Non-Proprietary Names (INNs) described by WHO from 2000. What is mapping? Mapping means that searchers get the same results regardless of which term they use, e.g. Vioxx (synonym) or rofecoxib(the preferred term).

27. Section 3.2 Deep Indexing – EMTREE Embase vs. PubMed : in-depth indexing + Emtree tree structure

28. Section 3.2 Embasevs PubMed 2 thesaurus assisted searches but different results!

29. Section 3.2 Embasevs PubMed This article, although present in Medline, is not indexed with ‘digoxin’ and therefore our search for ‘digoxin’ and ‘antibacterial agents’ did not find this article – it’s found in Embase.

30. Section 3.2 EmbasevsMEDLINE – Randomized Controlled Trails

31. Section 3.2 EmbasevsMEDLINE – Searching for Drugs