East by Southwest Third Annual Update in Nephrology Friday, September 6 – Sunday, September 8

1. East by Southwest Third Annual Update in Nephrology Friday, September 6 – Sunday, September 8 Sheraton Pittsburgh Hotel at Station Square Keynote speakers Arlene Chapman, MD Professor of Medicine, University of Chicago Chief, Section of Nephrology Gerald Appel, MD Professor of Medicine, Columbia University Medical Center Director of Glomerular Kidney Disease Center We gratefully acknowledge support from the following for this activity: Educational Grants DaVita Otsuka Relypsa, Inc. Dialysis Clinic, Inc. Mallinckrodt LLC Course directors Amar Bansal, MD Christos Argyropoulos, MD Assistant Professor of Medicine Chief, Division of Nephrology Renal-Electrolyte Division Assistant Professor of Medicine Section of Palliative Care and Medical Ethics University of New Mexico School of Medicine University of Pittsburgh School of Medicine Exhibits Amgen Otsuka AstraZeneca Relypsa, Inc.

2. Friday, September 6th, 2019 Saturday, September 7th, 2019 Sunday, September 8th, 2019

3. Learning objectives Program Overview The nephrology divisions at the University of Pittsburgh and University of New Mexico are proud to host the East by Southwest Third Annual Update in Nephrology. This year’s program will feature updates on topics that are relevant to clinical nephrology practice such as glomerular disease, novel therapies for diabetic kidney disease, polycystic kidney disease treatments, hemodialysis, kidney transplantation, and hypertension. Target Audience Nephrologists, advanced practice providers, nephrology fellows, internal medicine residents, and other practicing health care professionals with an interest in kidney disease management • Identify ways to measure and maintain residual renal function in hemodialysis • Describe ways to promote work-life balance and utilize strategies to reduce professional burn-out in nephrology • Understand the in vitro evidence for gadolinium associated toxicity • Identify the prevalence of sleep disorders in chronic kidney disease and develop management strategies • Incorporate novel therapeutics for rapidly progressive autosomal dominant polycystic kidney disease • Discuss novel treatment strategies and advances in the treatment of focal segmental glomerulosclerosis • Outline the most recent evidence in the management of ANCA associated vasculitis • Incorporate strategies to promote shared-decision making for patients with advanced chronic kidney disease • Summarize the latest evidence in contrast associated nephropathy • Describe the effect of potassium homeostasis on blood pressure regulation • Outline latest evidence in the use of SGLT2 inhibitors for preventing progression of chronic kidney disease • Develop strategies to increase patient referral for kidney transplantation • Incorporate novel strategies in the management of kidney allograft rejection University of Pittsburgh Faculty University of New Mexico Faculty Jane Schell, MDAssistant Professor of Medicine Steven Weisbord, MD Associate Professor of Medicine Arohan Subramanya, MDAssociate Professor of Medicine Linda Fried, MD Professor of Medicine and Epidemiology Christine Wu, MD Associate Professor of Medicine Rajil Mehta, MDAssistant Professor of Medicine Mark Unruh, MDChair, Department of Medicine Christos Argyropoulos, MD Chief, Division of Nephrology Brent Wagner, MD Chief, Renal Section, New Mexico VA Yue-Harn Ng, MD Assistant Professor of Medicine Eileen Barrett, MD Assistant Professor of Medicine

4. CME Accreditation and Designation Statement In support of improving patient care, the University of Pittsburgh is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME) and the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. The University of Pittsburgh School of Medicine designates this live activity for a maximum of 13.5 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in the activity. Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 13.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit. This educational activity is approved for 13.5 contact hours. Other health care professionals will receive a certificate of attendance confirming the number of contact hours commensurate with the extent of participation in this activity. Disclosures All individuals in a position to control the content of this education activity including members of the planning committee, speakers, presenters, authors, and/or content reviewers have disclosed all relevant financial relationships with any entity producing, marketing, re-selling, or distributing health care goods or services, used on, or consumed by, patients. The following relevant financial relationships were disclosed: • Dr. Linda Fried – DSMB member for Novonordisk. • Dr. Jane Schell – Reviewer for UpToDate. • Dr. Steven Weisbord – Consultant with Saghmos Therapeutics and Cytokinetics. • Dr. Gerald Appel – Receives grant/research support from Regulus, Bristol-Myers Squibb, EMD Serono, Achillion, Mallinckrodt, and Reata. Dr. Appel is on the CE Speakers’ Bureau for Genentech and Sanofi-Genzyme. He is a consultant for Alexion, Alnylam, Achillion, Apellis, Omeros, Genentech, Ionis, Mallinckrodt, Pfizer, Merck, Bristol-Myers Squibb, UpToDate, Gensyme-Sanofi, EMD Serono, Regulus, and Reata. No other planners, members of the planning committee, speakers, presenters, authors, content reviewers and/or anyone else in a position to control the content of this education activity have relevant financial relationships to disclose. Disclaimer The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by, the UPMC Center for Continuing Education in the Health Sciences, UPMC / University of Pittsburgh Medical Center or Affiliates and University of Pittsburgh School of Medicine. Reasonable efforts have been taken intending for educational subject matter to be presented in a balanced, unbiased fashion and in compliance with regulatory requirements. However, each program attendee must always use his/her own personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.

5. CME certificate can go here