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Biochemical Mechanism of Magnesium

Biochemical Mechanism of Magnesium. Mark H. Whitney, Jeffrey S. Knott, and Jayne L. Kalbfleisch. Central Nervous System. STRESS. CRF - Corticotropin Releasing Factor ACTH -Adrenocorticotrophic Hormone. Adapted from Classen and Porta, 1996. Central Nervous System. STRESS. Hypothalamus.

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Biochemical Mechanism of Magnesium

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  1. Biochemical Mechanism of Magnesium Mark H. Whitney, Jeffrey S. Knott, and Jayne L. Kalbfleisch

  2. Central Nervous System STRESS CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  3. Central Nervous System STRESS Hypothalamus CRF Pituitary CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  4. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Adrenal Cortex CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  5. ACTH Adrenal Cortex

  6. ACTH Adrenal Cortex cAMP Concentrations

  7. ACTH Adrenal Cortex cAMP Concentrations 20, 22 Lyase Activation

  8. ACTH Adrenal Cortex cAMP Concentrations 20, 22 Lyase Activation Cortisol Synthesis

  9. ACTH Adrenal Cortex cAMP Concentrations Liver 20, 22 Lyase Activation Cortisol Synthesis Glycogen Release

  10. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  11. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  12. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  13. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  14. Epinephrine Adenylate cyclase ATP cAMP Adapted from Coffee, 1998.

  15. P Epinephrine Adenylate cyclase ATP cAMP Protein Kinase A Phosphorylase Kinase Phosphorylase Kinase Adapted from Coffee, 1998.

  16. P P Epinephrine Adenylate cyclase ATP cAMP Protein Kinase A Phosphorylase Kinase Phosphorylase Kinase Glycogen Phosphorylase Glycogen Phosphorylase Adapted from Coffee, 1998.

  17. P P P Glycogen Glucose-1-phosphate Epinephrine Adenylate cyclase ATP cAMP Protein Kinase A Phosphorylase Kinase Phosphorylase Kinase Glycogen Phosphorylase Glycogen Phosphorylase Adapted from Coffee, 1998.

  18. ATP cAMP Protein Kinase A Phosphorylase Kinase Phosphorylase Kinase P P P Glycogen Glycogen Phosphorylase Glycogen Phosphorylase Glucose-1-phosphate GLYCOLYSIS Epinephrine Adenylate cyclase Adapted from Coffee, 1998.

  19. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  20. Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  21. Nervous Stimulation Adapted from Coffee, 1998.

  22. Ca Ca Ca Ca Ca Ca Ca Ca Ca Ca Sarcoplasmic Reticulum

  23. Nervous Stimulation Ca2+ Adapted from Coffee, 1998.

  24. Nervous Stimulation Ca2+ Troponin-C Ca2+ Adapted from Coffee, 1998.

  25. Muscle Contraction Nervous Stimulation Ca2+ Troponin-C Ca2+ Adapted from Coffee, 1998.

  26. Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Adapted from Coffee, 1998.

  27. Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Phosphorylase kinase-Ca2+ Adapted from Coffee, 1998.

  28. P Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Phosphorylase kinase-Ca2+ Glycogen Phosphorylase Glycogen Phosphorylase Adapted from Coffee, 1998.

  29. Phosphorylase kinase-Ca2+ P Glycogen Phosphorylase Glycogen Phosphorylase Glycogen Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Glucose-1-phosphate GLYCOLYSIS Adapted from Coffee, 1998.

  30. Phosphorylase kinase-Ca2+ P Glycogen Phosphorylase Glycogen Phosphorylase Glycogen Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Ca2+-calmodulin-protein kinase Glucose-1-phosphate GLYCOLYSIS Adapted from Coffee, 1998.

  31. Phosphorylase kinase-Ca2+ P P Glycogen Phosphorylase Glycogen Phosphorylase Glycogen Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Ca2+-calmodulin-protein kinase Glycogen Synthase Glycogen Synthase Glucose-1-phosphate GLYCOLYSIS Adapted from Coffee, 1998.

  32. Phosphorylase kinase-Ca2+ P P Glycogen Phosphorylase Glycogen Phosphorylase Glycogen Storage Glycogen Muscle Contraction Lactic Acid pH Nervous Stimulation Ca2+ Troponin-C Ca2+ Ca2+-calmodulin-protein kinase Glycogen Synthase Glycogen Synthase Glucose-1-phosphate GLYCOLYSIS Adapted from Coffee, 1998.

  33. Mg inhibits Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  34. Mg inhibits Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  35. Mg inhibits Central Nervous System STRESS Hypothalamus CRF Pituitary ACTH Liver Glycogen Cortisol Adrenal Cortex Adrenal Medulla Epinephrine Muscle Glycogen Muscle Glycogen CRF- Corticotropin Releasing Factor ACTH-Adrenocorticotrophic Hormone Adapted from Classen and Porta, 1996.

  36. Nervous Stimulation Adapted from Coffee, 1998.

  37. Ca Ca Ca Ca Ca Ca Ca Ca Ca Mg Mg Mg Mg Mg Mg Mg Mg Mg Mg Mg Sarcoplasmic Reticulum

  38. Phosphorylase kinase-Ca2+ P P Glycogen Phosphorylase Glycogen Phosphorylase Glycogen Nervous Stimulation Ca2+ Troponin-C Ca2+ Ca2+-calmodulin-protein kinase Glycogen Synthase Glycogen Synthase Muscle Contraction Glucose-1-phosphate GLYCOLYSIS Adapted from Coffee, 1998; Fry and Hall, 1996.

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