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Lymphatic System

Lymphatic System. Vessels, Organs and Tissues. Lymphatic System. Vessels: Connect to CV Lymphatics Capillaries Collecting vessels Trunks Transport fluid => lymph Organs: house immune cells LN Spleen Thymus Tissues Tonsils GALT MALT. Fluid Compartments. Capillary Dynamics

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Lymphatic System

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  1. Lymphatic System Vessels, Organs and Tissues

  2. Lymphatic System • Vessels: Connect to CV • Lymphatics • Capillaries • Collecting vessels • Trunks • Transport fluid => lymph • Organs: house immune cells • LN • Spleen • Thymus • Tissues • Tonsils • GALT • MALT

  3. Fluid Compartments • Capillary Dynamics • Hydrostatic/Hydraulic • Osmotic • Fluid Compartments • ICF • ECF • ISCF • Plasma • Lymph

  4. Lymphatic Capillary

  5. Lymph Flow

  6. Lymphatic Valve

  7. Lymphatic Vessels and Ducts

  8. Thoracic Duct

  9. Lymph Return

  10. Problem Lymph Return : Lymphedema

  11. Lymphatic Vessel Circuits

  12. Lymph Node: Location

  13. L.N. : Specimen

  14. Lymph Node: Gross Anatomy • 1. Afferent Lymphatics • 2. Cortex • 3. Germinal Center • 4. Capsule • 5. Medullary cord • 6. Valve • 7. Efferent Lymphatics

  15. LN Structure: CT and vessels • Capsule • Subcapsular sinus • Trabecula • Reticular CT stroma • Vessels • Types • Afferent • Efferent • Valves

  16. Lymph Node

  17. Lymph Node: Histology B cells T cells MO

  18. Lymph Node: Capsule Region

  19. Lymph Node: Cortex Lymphatic Nodule Germinal Center

  20. Lymph Node: Medulla

  21. Lymph Node: Medullary Cords Medullary Cords Sinusoids Macrophages

  22. L.N. Medullary Cells • P = Plasma cells (daughter cells of Activated B cells • M = Macrophages (mature monocytes in tissues)

  23. LN Histology Summary

  24. Diagnostics for Lymphatics and LN Lymphangiogram

  25. Lymphatic Problem: Lymphoma

  26. Lymphatic Nodule: Basic structure for All Lymphatic tissue

  27. Spleen: Location

  28. Spleen: Gross Anatomy

  29. Spleen: Histology Splenic Sinusoid

  30. Spleen Problems • Rupture • Cancer • Infection Hydatid cyst

  31. Thymus: Location

  32. Thymus: Gross

  33. Thymus Embryological Development • 1. Mandibular arch • 2. Hyoid arch • 3. Cervical sinus entry • 4. 3rd pharyngeal pouch • 5. 4th pharyngeal pouch • 6. Foramen cecum • 7. Thyroid • 8. Cervical sinus • 9. Thymus (3rd pouch) • 10. Thymus (4th pouch)

  34. Thymic Cell Development • 1. Thymic capsule • 2. Thymic nurse cells • 3. CT septa and BV • 4. Subcapsular epithelium (for the blood thymus barrier) • 5. Cortical Epithelial cells • 6. Medullary epithelial cells • 7. Dendritic cells • 8. Hassall’s Corpuscle • 9. Macrophages • 10. Cortex • 11. Medulla

  35. Thymic Organization

  36. Thymic Capsule, Septa and Lobules

  37. Thymus: Cortex

  38. Thymic Medulla

  39. Thymic Age Degeneration

  40. Thymic Problem Thymic Aplasia

  41. Tonsil: Location • Pharyngeal [Adenoids] • Palantine • Lingual • Tubal

  42. Palatine Tonsil

  43. Tonsil: Epithelial Histology

  44. Tonsil Lymphatic Nodules

  45. Tonsilar Crypt

  46. Tonsil Problem: Tonsillitis

  47. Gut Associated Lymphatic Tissue (GALT) Location

  48. GALT

  49. Peyer’s Patches

  50. Ileum Problems Inflammation Necrosis

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