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DNA Logic Gates

Explore the design and construction of robust DNA logic circuits using DNA hole-transport system. Learn about electron transport in DNA via Guanine oxidation and the innovative MDA/C orthogonal complementation. Discover the detection and operation of DNA logic gates for advanced AI applications.

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DNA Logic Gates

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  1. DNA Logic Gates Okamoto,A., Tanaka,K. and Saito,I. JACS126:2004. Presented by Nam Jin Wu Advanced AI Jounal Club

  2. Core • Goal • Construction of easily designable, robust and universal logic circuit using DNA hole-transport • KeyIdea • Designing DNA hole-transports equivalent to SOP expressions of logic gates Advanced AI Jounal Club

  3. DNA Hole-transport • Electron Transport in DNA is mainly due to oxidation process of the Guanine • The Guanine give an hole which can move in the DNA via hopping processes. • DNA hole transport promote oxidative damage to Guanine Advanced AI Jounal Club

  4. MDA:C as another Hole • MDA :Orthogonal Complemenation with ‘G’ • MDA/C vs MDA/T base pair • G-C >> G-T • MDA-T >> MDA-C Advanced AI Jounal Club

  5. DNA Hole-transport system • Designed DNA sequence • Hole-transport system • Program(X): G(Not) or MDA(Yes) • Input(Y): C(0) or T(1) • Output: electron transfer of a distal GGG site(Gb) 312nm Advanced AI Jounal Club

  6. Hole detection method • Detecting the oxidative strand cleavage at the proximal and the distal ‘GGG’ 32P-ATTTATAGTGTGGGTT MDA/G TTGGG 32P-ATTTATAGTGTGGGTT MDA/G TTGGG 32P-ATTTATAGTGTGGGTT MDA/G TTGGG 32P-ATTTATAGTGTGGGTT MDA/G TTGGG 32P-ATTTATAGTGTGGGTT MDA/G TTGGG 32P-ATTTATAGTGTGGGTT MDA/G TTGGG Advanced AI Jounal Club

  7. DNA logic gate system • Logic gate by serial hole-transports Advanced AI Jounal Club

  8. OR gate SOP expression A B Advanced AI Jounal Club

  9. A full-adder operation ∑ Cout Advanced AI Jounal Club

  10. Conclusions • Prerequisites for designing DNA logic gates • Logic bases, MDA and G, are applied to a YES and a NOT gate, respectively because complementary pyrimidines are orthogonal • Logic bases are arranged in series act as an AND logic • Conversion of Boolean expression for OR logic and combinational logic to standard SOP expression • A way to design complicated combinational logic circuits Advanced AI Jounal Club

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