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Sofosbuvir-Ledipasvir +/- Ribavirin in GT-1 LONESTAR Trial

Phase 2a . Treatment Naïve and Treatment Experienced. Sofosbuvir-Ledipasvir +/- Ribavirin in GT-1 LONESTAR Trial. Source: Lawitz E, et al. Lancet. 2014:383:515-23 . Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1 LONESTAR Trial: Features.

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Sofosbuvir-Ledipasvir +/- Ribavirin in GT-1 LONESTAR Trial

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  1. Phase 2a Treatment Naïve and Treatment Experienced Sofosbuvir-Ledipasvir +/- Ribavirin in GT-1LONESTAR Trial Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  2. Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1LONESTAR Trial: Features Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  3. Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1LONESTAR Trial: Results 0 8 12 16 20 24 Week n =20 SVR12 Cohort ANaïven = 60 SOF-LDV n = 21 SVR12 SOF-LDV + RBV n = 19 SVR12 SOF-LDV n = 19 SVR12 Cohort BExperiencedn = 40 SOF-LDV n = 21 SVR12 SOF-LDV + RBV Drug DosingSofosbuvir-Ledipasvir: 400/90 mg fixed dose combination one pill once dailyRibavirin (weight-based and divided bid): 1000 mg/day if < 75kg or 1200 mg/day if ≥ 75kg N =14 Abbreviations: SOF = sofosbuvir; LDV= ledipasvir; RBV = ribavirin Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  4. Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1LONESTAR Trial: Results LONESTAR: SVR 12, by Cohort and Treatment Regimen 19/20 21/21 18*/19 18/19 21/21 Cohort A: Treatment-Naive Cohort B: Experienced (with PI) *One patient lost to follow-up; SOF = sofosbuvir; LDV= ledipasvir; RBV = ribavirin; PI = protease inhibitor Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  5. Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1LONESTAR Trial: Adverse Events Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  6. Sofosbuvir-Ledipasvir +/- Ribavirin in Naïve & Experienced GT1LONESTAR Trial: Conclusion Source: Lawitz E, et al. Lancet. 2014:383:515-23.

  7. This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects. Hepatitis C Onlinewww.hepatitisc.uw.edu Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/ Funded by a grant from the Centers for Disease Control and Prevention.

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