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THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT. We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely
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THE REGISTRY OF THE INTERNATIONAL SOCIETY FOR HEART AND LUNG TRANSPLANTATION: EIGHTEENTH ANNUAL REPORT
We wish to extend our sincere thanks to the many thoracic transplant surgeons, physicians and data coordinators in transplant programs throughout the world whose timely and accurate submission of data has made these analyses possible. ACKNOWLEDGMENTS:
% donors 50-55 % donors 50+ 12% HEART TRANSPLANTATION 9% Percent of Donors by Age Number of Transplants * 6% 3% * * Numbers may be low due to incomplete reporting.
AGE DISTRIBUTIONOF HEART RECIPIENTS (1982-2000) % of Transplants
INDICATIONS ADULT HEART TRANSPLANTATION
AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS 386 374 375 365 363 362 352 347 346 326 332 255 194 Number of Transplants 128 111 75 42 11 9
< 1 Year 1-10 Years 11-17 Years PEDIATRIC HEART TRANSPLANTATIONINDICATIONS BY AGE (1982-1999)
HEART TRANSPLANTATION ACTUARIAL SURVIVAL(1982-2000) Half-life =9.1 years Conditional Half-life = 11.6 years N=52,195
ADULT HEART TRANSPLANTATIONACTUARIAL SURVIVAL Survival (%) All comparisons with 1980-1987 are significant at p < 0.0001
ADULT HEART RE-TRANSPLANTATION(1982-1999) 1 Year Patient Survival (%)
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Latest period in cohort N=38,943
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=38,943
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=26,250
PEDIATRIC HEART TRANSPLANTATIONACTUARIAL SURVIVAL (1982-2000) All comparisons with <1 year significant at p < 0.0001
PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Earliest period in cohort N=3,760
PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=3,760
PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY * * Latest year in cohort N=2,465
PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=2,465
PEDIATRIC HEART TRANSPLANTATIONRISK FACTORS FOR 5 YEAR MORTALITY N=2,465
FUNCTIONAL STATUS Heart (April 1994-Dec. 2000)
EMPLOYMENT STATUS Heart (US Data: April 1994-Dec. 2000)
REHOSPITALIZATION POST HEARTTRANSPLANTATION(April 1994 - Dec. 2000)
HEART TRANSPLANT MAINTENANCEIMMUNOSUPPRESSION % of Patients
HEART TRANSPLANTATIONDonor age versus Ejection Fraction yr 1 to yr 2
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691
ADULT HEART TRANSPLANTATIONRISK FACTORS FOR CAV WITHIN 3 YEARS N=7,691
MALIGNANCY POST-HEART TRANSPLANTATION(April 1994-December 2000) 1-Year Followup 5-Year Followup
HEART TRANSPLANTS: CAUSE OF DEATH(1982-2000) Cause of Death (%) Timing of Death
HEART-LUNG TRANSPLANTATIONACTUARIAL SURVIVAL (1982-2000) Half-life = 2.8 years Conditional Half-life = 8.2 years N=2,550 Survival (%)
1412 1386 1385 1331 1325 1284 LUNG TRANSPLANTATION 1176 1062 887 Mean Donor Age 675 404 184 74 38 7 4
ADULT LUNG TRANSPLANTATIONINDICATIONS (1983-2000) SingleLung Bilateral/Double Lung
85 86 80 PEDIATRIC LUNG TRANSPLANTATIONAGE DISTRIBUTION (1986-2000) 68 64 65 50 47 45 Number of Transplants 41 19 6 3 4 1
LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1983-2000) Double lung: 1/2-life = 4.5 Years; Conditional 1/2-life = 7.9 Years Single lung: 1/2-life = 3.6 Years; Conditional 1/2-life = 5.7 Years All lungs: 1/2-life = 3.8 Years; Conditional 1/2-life = 6.3 Years
ADULT LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1988-2000) Comparison of 1988-1992 vs. 1997-2000 was significant at p = 0.002
PEDIATRIC LUNG/HRT-LUNG TRANSPLANTATIONACTUARIAL SURVIVAL(1984-2000)
ADULT LUNG TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY * * Earliest period in cohort N=9,653
ADULT LUNG TRANSPLANTATIONRISK FACTORS FOR 1 YEAR MORTALITY N=9,653