130 likes | 446 Views
Granulation. Is done to: improve flow properties of the mix improve compression properties of the mix prevent segregation of components in powder mix reduce production of toxic dust reduce possibility of ‘cake’ formation increase convenience of transport. Wet Granulation.
E N D
Granulation • Is done to: • improve flow properties of the mix • improve compression properties of the mix • prevent segregation of components in powder mix • reduce production of toxic dust • reduce possibility of ‘cake’ formation • increase convenience of transport CHEE 440
Wet Granulation • particle bonding mechanisms • adhesion and cohesion forces in immobile liquid films • interfacial forces in mobile liquid films • solid bridges • attractive forces between solid particles CHEE 440
Wet Granulation • Wet granulation equipment: • high shear granulator CHEE 440
Wet Granulation • low shear granulator
Wet Granulation fluidized bed granulator CHEE 440
Wet Granulation • spray granulation CHEE 440
Wet Granulation • pelletizers CHEE 440
Dry Granulation CHEE 440