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Medical Immunology 544 Fall 2008 Dept. of Microbiology and Molecular Genetics

Medical Immunology 544 Fall 2008 Dept. of Microbiology and Molecular Genetics. Immunology 2008 Lecture 1 7 October. Immunology Poses Challenges. 1) New and unique concepts , e.g . "specificity", gene rearrangements, etc . 2) Much phenomenology - complex systems

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Medical Immunology 544 Fall 2008 Dept. of Microbiology and Molecular Genetics

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  1. Medical Immunology 544 Fall 2008 Dept. of Microbiology and Molecular Genetics

  2. Immunology 2008 Lecture 1 7 October

  3. Immunology Poses Challenges 1) New and unique concepts, e.g. "specificity", gene rearrangements, etc. 2) Much phenomenology - complex systems which are still poorly understood. 3) Much jargon and many acronyms, unique vocabulary; new words, familiar words with new meanings. 4) Conflicts over facts and interpretations

  4. “Why do I need to know this?” • Autoimmune disease (rheumatoid arthritis, lupus erythematosus, IDDM, many others) • Immunodeficiency (genetic, infectious, iatrogenic…) • Allergy (food, drugs, airborne allergens [asthma]…) • Transplantation and tumor biology • Vaccination (required vs. optional…) • Technology: serology, tissue typing, hybridomas; tools for diagnosis, therapy and research.

  5. Responsibilities 1) Core notes; read ahead. 2) Lectures & Clinical Correlates (3) 3) Handouts, supplementary material, 3 problem sets… (…numbered & posted on Web site) 4) POPS, Patient Oriented Problem Solving sessions (2) Small group exercises, participation is required ● Jaundiced Baby; blood groups, etc. ● Transplantation Immunology 5) e-mail- check it every day, unpack your inboxes

  6. Exams Two Midterm Exams (20% each), one Final Exam (60%) Multiple choice questions, mostly NBME formats

  7. Texts Recommended: The Immune System, Parham (useful, compact text) Medical Immunology, Parslow, Stites, Terr and Imboden, Eds. (reference source, not a text) Other popular texts… Cellular and Molecular Immunology, Abbas, Lichtman & Pillai Immunobiology, Janeway and Travers, Kuby Immunology, Goldsby, Kindt and Osborne Immunology, Male, Brostoff, Roth & Roitt

  8. COURSE TOPICS ANTIBODIES (Structure, function, genetics…) CELLULAR IMMUNOLOGY Leukocytes (T & B-cells, MF, etc.) Cell interactions (MHC, adhesion & signalling, etc.) ANATOMY & ONTOGENY of immune system ALLERGY, AUTOIMMUNITY, IMMUNODEFICIENCY VACCINATION, TUMOR IMMUNOLOGY THREE CLINICAL CORRELATES: Monoclonal Gammopathies (Week 11[3], Gupta) Rheumatoid diseases (Week 13[5], Andrews) AIDS (Week 15[7], Robinson) TWO POPS SESSIONS: JAUNDICED BABY (Week 12[4]) TRANSPLANTATION IMMUNOLOGY (Week 15[7])

  9. Techniques ● Precipitin curve ● Ouchterlony ● ELISA/RIA ● Equilibrium Dialysis ● Adoptive Transfer ● Complement Fixation ● PFC assay Will also use Southern & Western blots, PCR, etc…

  10. Experiments ● Ada & Byrt (Hot Ag suicide) ● Mishell & Dutton (3HTdR suicide) ● Mitchell & Miller (T & B cells) ● Zinkernagel and Dougherty (MHC-restricted recognition) ● Carrier Effect (T/B interactions, haptens & carriers) ● Resistance to Listeria/Mycobacterium These experiments will serve to clarify underlying principles rather than simply present results to memorize.

  11. Core Notes • Mostly organized around lectures • Read ahead • Chapters begin with BOXED INTRODUCTION • Chapters end with STUDY QUESTIONS • Material in [square brackets] is parenthetical • Please report errors & omissions

  12. Handouts today • Immunology Background Survey - please turn this in at the end of today’s lectures • “Roadmap” – for second hour On web site: Examination and Grading Policy Lecture Schedule Core Notes PDF files Handouts other stuff…

  13. Helpful Advice STUDY WITH A SMALL GROUP • An effective “group” entails: • Scheduled meetings • Pre-arranged assignments

  14. George Gutman Office: B250 Med Sci, Ext. 46593 medmicro@eee.uci.edu Medical Immunology Web pages: http://jeeves.mmg.uci.edu/immunology

  15. Fin

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