1 / 16

Typhus By Tim Waer

Typhus By Tim Waer. What is Typhus?. Chills Cough High Fever Joint Pain Low BP Severe Headache/Muscle Pain Stupor Delirium Rash that begins on chest and spreads to limbs (but not palms of hands or soles of feet). What causes Typhus?. Rickettsia prowazekii : epidemic typhus

ilya
Download Presentation

Typhus By Tim Waer

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. TyphusBy Tim Waer

  2. What is Typhus? • Chills • Cough • High Fever • Joint Pain • Low BP • Severe Headache/Muscle Pain • Stupor • Delirium • Rash that begins on chest and spreads to limbs (but not palms of hands or soles of feet)

  3. What causesTyphus? • Rickettsiaprowazekii: epidemic typhus • Rickettsiatyphi : endemic (murine) typhus • Gram (-), non-motile, obligate intracellular parasite, aerobic bacteria

  4. Fun Fact: Rickettsiaprowazekii and the origin of mitochondria • Andersson et al (1998) • Similar functional profile of genome to mitochondria • Similar ATP production mechs • Possible insight into endosymbiosis

  5. History of Typhus • Commonly found in prisons/crowded areas • Lends to its common name of “Jail Fever”

  6. Where Does Typhus Occur?

  7. How Does Typhus Spread? • Two modes of transmission: • Epidemic typhus – Lice to humans • Endemic typhus – Fleas to humans

  8. Rickettsia-Host Cell Interaction • Entry: • Interaction with Outer Membrane Protiens • Phagocytosis

  9. Escape from Phagosome and Spread to Other Cells • Lysing of Phagosomal Membrane • Divide by Binary Fission • Spread due to burst of cell • Lack Actin-Polymerization machinery

  10. Natural Defense and RickettsialSurvival

  11. When Things Go Bad

  12. Diagnosis • Should be made based on clinical findings • Complete blood count to check for anemia/low platelets • Test for increased levels of typhus antibodies

  13. Treatment • Easily treated with a mix of broad-spectrum antibiotics • Most common include doxycycline, tetracycline and chloramphenicol. • Originally, vaccine dangerous to produce, now just not worth it

  14. Prognosis • Infrequent relapses • Without treatment, death resulted in 10-60% of cases for epidemic typhus • <2% for endemic typhus • Prompt treatment leads to prompt recovery

  15. Prevention • Good Hygiene • Avoid areas where one may encounter rats/fleas and lice. • Bathe regularly • Use insecticides • Wash clothes regularly

  16. References • Anderson et al. “The genome sequence of Rickettsiaprowazekii and the origin of mitochondria”. Nature 396. (1998) pg 133-140. • Immunopaedia.org, 2010. Web. 4 April 2012. http://www.immunopaedia.org.za/index.php?id=257 • Mayer, Gene. Microbiology and Immunology. Columbia, SC: The Board of Trustees of the University of South Carolina, 2010. • Parola, Philippe and Didier Raoult. Rickketsial Diseases. Informa Healthcare, 2007. • “Rickketsia”. Wikipedia, The Free Encyclopedia. Wikimedia Foundation Inc. 21 Feb 2012. Web. 4 April 2012. • “Typhus”. Wikipedia, The Free Encyclopedia. Wikimedia Foundation, Inc. 30 March 2012. Web. 4 April 2012.

More Related