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NON-LETHAL CHEMICAL AGENTS. TOXICITY of CN and CS. DEFINITION OF TERMS. m 3 = Cubic meter (Approximately 35 cubic feet) gm = Gram (0.353 oz.) mg = Milligram (0.001 grams - to convert grams to milligrams multiply by 1,000) cc = Cubic centimeter (0.000001 m 3 or 1.0 gm) 1 oz. = 28.350 gm
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NON-LETHAL CHEMICAL AGENTS TOXICITY of CN and CS
m3 = Cubic meter (Approximately 35 cubic feet) • gm = Gram (0.353 oz.) • mg = Milligram (0.001 grams - to convert grams to milligrams multiply by 1,000) • cc = Cubic centimeter (0.000001 m3 or 1.0 gm) • 1 oz. = 28.350 gm • 66 minutes = time average man uses 1 m3 of air
MEDIAN INCAPACITATION DOSAGE (IC50) - The amount of inhaled vapor or aerosol which is sufficient to incapacitate 50% of exposed personnel. Usually expressed in milligrams per minute in one cubic meter of air.
INCAPACITATION CONCENTRATION TIME (ICT50) - • Concentration (IC50) multiplied by the time (t) of exposure that • incapacitates 50% of exposed personnel. Usually expressed in • minutes of exposure. • ! .004 mg/m3 - smallest amount a human can detect. • (British Government Study) • ! 0.5 mg/m3 - amount that riot bystanders usually retreat at. • (British Government Study) • ! 4.0 mg/m3 - amount that rioters will usually disperse at. • (British Government Study)
MEDIAN LETHAL DOSAGE (LC50) - The amount of inhaled vapor or aerosol which is sufficient to kill 50% of exposed personnel. Usually expressed in milligrams per minute in one cubic meter of air.
LETHAL CONCENTRATION TIME (LCT50) - Concentration (LC50) multiplied by the time (t) of exposure that is lethal to 50% of exposed personnel. Usually expressed in minutes of exposure.
SAFETY FACTOR - Ratio between the lethal and incapacitating dose of an agent (LCT50/ICT50). CN: IC50 = 20 milligrams per minute / cubic meter of air. LC50 = 14,000 milligrams per minute / cubic meter of air SAFETY FACTOR OF 700 CS: IC50 = 20 milligrams per minute / cubic meter of air. LC50 = 25,000 milligrams per minute / cubic meter of air SAFETY FACTOR OF 1,250