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Adrenergic receptor

Summary: The adrenergic receptor signaling pathway positively regulates the force of heart contraction.

imani-stevens
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Adrenergic receptor

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  1. Summary: • The adrenergic receptor signaling pathway positively regulates the force of heart contraction. • nNOS positively regulates GC (shown in another paper) to enhance adrenergic receptor signaling, and therefore enhance the force of heart contraction PMCA4 binds to and inhibits nNOS. This leads to a decrease in the force of adrenergic receptor-mediated heart contraction. PMID:17242280 Adrenergic receptor agonist (e.g. adrenalin) PMCA4 (aka ATP2B4, P23634) Adrenergic receptor nNOS (Q92OJ4) NO Existing GO terms: MF: nitric-oxide synthase inhibitor activity ; GO:0036487 BP: adrenergic receptor signaling pathway involved in heart process ; GO:0086023 positive regulation of the force of heart contraction by epinephrine ; GO:0003059 regulation of [adrenergic receptor signaling pathway involved in heart process] ; GO:1901204 negative regulation of [adrenergic receptor signaling pathway involved in heart process] ; GO:1901205 positive regulation of [adrenergic receptor signaling pathway involved in heart process] ; GO:1901206 Need terms for: [adrenergic receptor signaling pathway] involved in [positive regulation of the force of heart contraction] & regulation of [above term]…. Guanylatecyclase (GC) positive regulation of the force of heart contraction

  2. Suggested new GO terms: [adrenergic receptor signaling pathway] involved in [positive regulation of the force of heart contraction] Essentially we need regulation of the above term, but this would create a ‘regulation of regulation’ (ROR) term. Can we condense it to: [negative regulation of adrenergic receptor signaling pathway] involved in[negative regulation of the force of heart contraction] [positive regulation of adrenergic receptor signaling pathway] involved in [positive regulation of the force of heart contraction]

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