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Ribozymes (RNA Enzymes)

Ribozymes (RNA Enzymes). David Peterson. Enzymes. Catalyze reactions Very specific Act on substrates Active site. Enzymes Bind Substrates. Enzymes Bind Substrates. Enzymes Bind Substrates. Structure of RNA and DNA. Information Flow in Cells The Central Dogma of Molecular Biology.

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Ribozymes (RNA Enzymes)

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  1. Ribozymes(RNA Enzymes) • David Peterson

  2. Enzymes Catalyze reactions Very specific Act on substrates Active site

  3. Enzymes Bind Substrates

  4. Enzymes Bind Substrates

  5. Enzymes Bind Substrates

  6. Structure of RNA and DNA

  7. Information Flow in Cells The Central Dogma of Molecular Biology DNA RNA Protein Transcription Translation

  8. Semiconservative DNA Replication

  9. Amino acids combine to make peptides and proteins

  10. mRNA Splicing

  11. Ribosomes • Site of protein synthesis • Made of RNA and protein

  12. Tetrahymena thermophila

  13. Self-Splicing RNA Cech, Zaug, and Grabowski.1981. Cell 27: 487-496

  14. Single-Stranded RNA Can Form Intramolecular Base Pairs

  15. Intramolecular H-bonds in the Tetrahymena Ribozyme

  16. 3D Structure of the Self-Splicing Intron

  17. Ribosomes • Site of protein synthesis • Made of RNA and protein

  18. Nobel Prize in Chemistry 1989 Tom Cech Sidney Altman

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