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CJD and Kuru: Prion Viruses

CJD and Kuru: Prion Viruses. By: Danny Nemeth. Prion. infectious agent composed of protein in a misfolded form. CJD. Creutzfeldt-Jakob Disease neurodegenerative disorder year of onset of illness. Structure. no Nucleic acids mass of 27,000 - 30,000 daltons 145 amino acids

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CJD and Kuru: Prion Viruses

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  1. CJD and Kuru: Prion Viruses By: Danny Nemeth

  2. Prion • infectious agent composed of protein in a misfolded form

  3. CJD • Creutzfeldt-Jakob Disease • neurodegenerative disorder • year of onset of illness

  4. Structure • no Nucleic acids • mass of 27,000 - 30,000 daltons • 145 amino acids • Structure unknown

  5. Cause • promotes refolding of native proteins • mass of misfolded proteins disrupts cell function

  6. ALWAYS FATAL!

  7. Symptoms • Neurological • Depression • Confusion • loss of coordination and balance • progressive blindness

  8. Transmission • GENETICS! • Defective HGH • CANNIBALISM!

  9. KURU • Misfolded Proteins • Cannibalism • Brains

  10. Symptoms • Coordination problems • Difficulty walking • Swallowing difficulty • Tremors and muscle jerks

  11. Treatment and Prognosis • NONE!  • Prognosis • Death after 1 year of symptoms

  12. Stuff I Used • http://www.cjdsurveillance.com/abouthpd.html • http://www.cdc.gov/ncidod/dvrd/cjd/index.htm • http://en.wikipedia.org/wiki/Kuru_(disease) • http://en.wikipedia.org/wiki/Creutzfeldt%E2%80%93Jakob_disease • http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002355/

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