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“La peste” Arnold Bochlin, Basilea, Kunstmuseum

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“La peste” Arnold Bochlin, Basilea, Kunstmuseum

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  1. Programma di Microbiologia Clinica 2012-2013 saverio.parisi@unipd.itEziologia, Epidemiologia, Diagnosi, Marcatori di progressione e di risposta alla terapiaPrincipali metodiche diagnostiche in microbiologiaInfezioni del Sistema Nervoso CentraleInfezioni del Sistema Respiratorio

  2. Programma 2012-2013HAV, HBV, HCVHIVVirus erpeticiGastroenteritiFebbri emorragiche e virus emergentiInfezioni OspedaliereInfezioni micoticheMalattie sessualmente trasmesse

  3. “La peste” Arnold Bochlin, Basilea, Kunstmuseum

  4. HIV-1

  5. MMWR June 5, 1981 / Vol. 30/ No. 21Epidemiologic Notes and ReportsPneumocystis Pneumonia --- Los AngelesIn the period October 1980-May 1981, 5 young men, all active homosexuals, were treated for biopsy-confirmed Pneumocystis carinii pneumonia at 3 different hospitals in Los Angeles, California. Two of the patients died. All 5 patients had laboratory-confirmed previous or current cytomegalovirus (CMV) infection and candidal mucosal infection. Case reports of these patients follow”.“Patient 1: A previously healthy 33-year-old man developed P. carinii pneumonia and oral mucosal candidiasis in March 1981 after a 2-month history of fever associated with elevated liver enzymes, leukopenia, and CMV viruria. The serum complement-fixation CMV titer in October 1980 was 256; in may 1981 it was 32.* The patient's condition deteriorated despite courses of treatment with trimethoprim-sulfamethoxazole (TMP/SMX), pentamidine, and acyclovir. He died May 3, and postmortem examination showed residual P. carinii and CMV pneumonia, but no evidence of neoplasia…………….”

  6. “……Da quel giorno la furia del contagio andò sempre crescendo: in poco tempo, non ci fu quasi più casa che non fosse toccata: in poco tempo la popolazione del lazzeretto, al dir del Somaglia citato di sopra, montò da duemila a dodici mila: più tardi, al dir di quasi tutti,arrivò fino a sedici mila…….”A Manzoni I Promessi sposi

  7. Principali malattie nel mondo: stime OMS 1999 % del totale 6.7 6.2 6.2 5.0 4.1 4.1 3.5 3.1 2.3 • 1 Infezioni acute delle basse vie respiratorie • 2 HIV/AIDS • 3 Patologie perinatali • 4 Malattie diarroiche • 5 Ischemia cardiaca • 6 Depressione maggiore unipolare • 7 Malattie cerebrovascolari • 8 Malaria • 12 Tubercolosi Adattata da: The World Health Report 2000, OMS, Ginevra

  8. Principali malattie in Africa: stime OMS 1999 % del totale • 1 HIV/AIDS • 2 Malaria • 3 Infezioni acute delle basse vie respiratorie • 4 Malattie diarroiche • 5 Patologie perinatali • 6 Morbillo • 7 Patologie della gravidanza • 8 Tubercolosi • 9 Malattie congenite • 10 Incidenti stradali 19.9 9.9 8.5 6.5 6.5 4.7 3.4 2.3 1.7 1.7 Adattata da: The World Health Report 2000, OMS, Ginevra

  9. Principali cause di morte nel mondo: stime OMS 1999 % del totale 12.7 9.9 7.1 4.8 4.8 4.2 4.0 3.0 • 1 Ischemia cardiaca • 2 Malattie cerebrovascolari • 3 Infezioni acute delle vie respiratorie • 4 HIV/AIDS • 5 Malattia ostruttiva cronica polmonare • 6 Patologie perinatali • 7 Malattie diarroiche • 8 Tubercolosi Adattata da: The World Health Report 2000, OMS , Ginevra

  10. Principali cause di morte in Africa: stime OMS 1999 % del totale • 1 HIV/AIDS • 2 Infezioni acute della basse vie respiratorie • 3 Malaria • 4 Malattie diarroiche • 5 Patologie perinatali • 6 Morbillo • 7 Tubercolosi • 8 Malattie cerebrovascolari 20.6 10.3 9.1 7.3 5.9 4.9 3.4 3.2 Adattata da: The World Health Report 2000, OMS, Ginevra

  11. “Twenty years have passed since the world first became awere of AIDS. Over those 20 years, the epidemic has spred further and its impact has been more severe than anyone could have immagined.”Peter Piot, Executive Director UNAIDS, New York, June 2001

  12. HIV/AIDS dopo 20 anni • Causa del 2% di tutte le morti nel mondo • Causa del 14% delle morti dovute a malattie infettive nel mondo • Causa del 20% delle disabilità nel mondo • Causa del 25% delle morti da tubercolosi nel mondo • Principale causa di morte in giovane età nel mondo • Responsabile del 75% delle malattie infettive in America Latina e Caraibi

  13. La fine dell’AIDS? New York Times Magazine, November 10 1996 Newsweek, December 2, 1996

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