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Aerobic Respiration. Beyond Glycolysis Page 174-177. 1 Glucose + 2 ADP + 2 P i + 2 NAD + 2 pyruvate + 2 ATP + 2 NADH +2 H + All happens in the cytoplasm Next step is to get the pyruvate into the mitochondria. Glycolysis review. Mitochondria has two membranes
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Aerobic Respiration Beyond Glycolysis Page 174-177
1 Glucose + 2 ADP + 2 Pi + 2 NAD+ 2 pyruvate + 2 ATP + 2 NADH +2 H+ • All happens in the cytoplasm • Next step is to get the pyruvate into the mitochondria Glycolysis review
Mitochondria has two membranes • Pyruvate passively diffuses through the outer • Undergoes facilitated diffusion to go through inner • Once inside the mitochondrial matrix, pyruvate is acted upon by thepyruvate dehydrogenase complex • Complex catalyzes 3 reactions Pyruvate Oxidation
Reaction 1: • Decarboxylation • A carbon is removed Pyruvate Oxidation
Reaction 2: • Dehydrogenation • 2 electrons and a proton are transferred to NAD+ Pyruvate Oxidation
Reaction 3: • RXN with CoA • Coenzyme A is added forming acetyl-CoA Pyruvate Oxidation
A derivative of ATP • All organisms sequenced to date encode enzymes for the synthesis of CoA • Also involved in synthesis and oxidation of fatty acids Coenzyme A
2 pyruvate + 2 NAD+ + 2 CoA 2 acetyl-CoA + 2 NADH + 2 H+ + 2 CO2 Pyruvate oxidation
