Best Healthcare Startups to Watch for 2019

1. 2019, Vol.7,Issue-1 www.insightscare.com BEST HEALTHCARE STARTUPS TO WATCH FOR2019

4. Artificial Intelligence: A Gatewayto Enhanced Healthcare

5. Wrobotics.WhileAI is booming across various industries, inhealthcare,its huge impact promises tobe ouldn’t it be amazing if you are reminded of your medications by a virtual assisting nurse or thevirtual assistant, a helper aiding you in your daily routine? Today, this is easily achieved by implementing AIand genuinely life-transforming. Right from clinical research to hospital care, insurance and drug development,healthcare is undergoing a paradigm shift with AI and has evolved to reduce expenditure and improving patientoutcomes. One of AI’s biggest potential benefits is to assist people stay healthy so they don’t need a doctor, not at least asoften as they might be visiting already. Technology applications and apps not only encourage healthier behavior in individuals but put consumers in control of ownwell-being. With AI, the healthcare professionals are gaining a deep understanding of the day-to-day patterns and needs of the people at the tip of their fingers, which in turn provides better feedback, guidance, and support for staying healthy. This advanced technology is already being used to detect major diseases, like cancer, more precisely and that too,in the early stages. Adding to this/Additionally, the implementation of AI is enabling review and translation of mammograms with over thirty times faster with 99% accuracy, hence reducing the need forbiopsies. The advancement doesn’t stop here. The medical devices and consumer wearable with the AI touch can be used to manage an early-stage heart disease allowing doctors to monitor and rectify potentially life-threatening diseases atan earlystage. By observing the whole scenario, there is no doubt, that AI holds huge potential to transform end of life care. Thus,it helps others remain independent for longer without the need for hospitalization. AI combined with theadvancements in humanoid design are enabling robots to cross the borders of ‘communications’ and other social interactions with people to keep the old mindssharp.

6. CONTENTS 14 ARTICLE 20 Tech-trend 5 cutting-edge trends ofHealthcare Startups CXO Standpoint Tech-spotlight EmpoweringPatients throughTechnology 10 Acorn Biolabs HelpingPeopleLiveaLonger HealthierTomorrow 16 BabyMed HealthyMothers, HealthyBabies 22 Biome Analytics Clinical Performance Solutions forHigh-performing CardiovascularCenters

7. 26 ConversaHealth EnhancingCommunication, Building Relationships, and Revampingthe CareExperience 30 Micrima A Leading Organization Developing Technologyfor Breast CancerScreening 34 NemauraPharma Offering PreciseUser- friendlySkin-based Drug DeliveryTechnologies 38 TransformativeAI RevolutionizingHealthcare with DeepLearning

8. DynamicStartups Re-transforming HealthcareSpace BestHEALTHCARE STARTUPS TO WATCH FOR2019 Thealthcare providers oftenget stuck in few ambiguous situationsregardingtheenhancement of patient he ability of advanced technologies in solving a wide range of issues for patients, hospitals, andthe healthcare industry is the impulse behind its sudden rising implementation in healthcare.However, care, helping people in this competitive world, along with providing cost-effectivesolutions. Considering these issues, most of the organizations are implementing advanced technology. These organizations are increasingly looking towards evolved real-time analytics such as AI and Machine Learning to cover the processing and data delivery. Implementation of real-time analytics assists physicians to detect and rectify diseases quickly, reducing time-to-time treatment and care costs. This eventually leads to better patient care andoutcomes. With this regard, we have come up with ‘Best Healthcare Startups to Watch for 2019’ issue in which we have introduced the leading organizations that are spearheading the healthcare field with their innovative servicesand solutions. In our issue ‘Best Healthcare Startups to Watch for 2019’, we have introduced the leading and dynamic startups that are spearheading the healthcare space with their astounding services and solutions. We have presented, Acorn Biolabs, a healthcare technology company focused on delivering easy, affordable and non-invasive live cell collection, analysis and cryopreservation service; BabyMed which is an integrated and innovative mobile health platform that provides easy and affordable access to reliable maternal and child health care information and services; Biome Analytics which offers cardiovascular performance solutions that combine machine learning technologies with human-driven insights to improve clinical and financial performance; Conversa Health whichis a clinically-intelligent conversation platform helps healthcare organizations deliver smart, automated, patient conversation experiences that are patient profile driven and lead to more meaningful patient relationships, better population management, improved care coordination, and quality outcomes; Micrima, the leading company that helps to detect breast cancer at an early stage with its innovative product; Nemaura Medical, a private pharmaceutical company that offers apt, reliable, and minimally invasive skin-based drug delivery technologies; Transformative AI which is the leading start-up that blends AI and novel analysis techniques employed at CERN and provides distinctive solutions to the clients; Soul Insole whose bio-mechanically designed shape of the Shoe Bubble effectively redistributes pressure evenly across the foot to relieve pressure from the heel and forefoot; Neurotrack that uses clinically proven science to help you assess and improve your memory over time; and Lucidium Health which enhances Healthcare for people at large through improving the current research processes by using AI-enabled, secure and intuitive platform to connect individuals & researchorganizations. We have also encompassed CXO article ‘Empowering Patients through Technology’ written by Dimas Francisco Silva Jr, Medcloud Founder andCEO. Our in-house editors have also scripted amazing article on ‘5 Cutting-edge Trends of Healthcare’ whichwould shed some light ontech-advancements. So, flip through the pages of the magazine and enjoy the journeys ofStartups!

9. Editor-in-Chief Pooja M.Bansal Senior Editor AnishMiller Managing Editor Ashwini S.Deshpande Executive Editor StellaAndrew Contributing Editors Aishwarya,Shambhavi Visualiser DavidKing Art & Design Head AmolKamble Art & Design Assistant PoonamMahajan Co-designer PaulBelin Art & Picture Editor SavitaPandav Business Development Manager PeterCollins Marketing Manager MarryD'Souza Business Development Executive MarkWilliams Sales Executives John, Amy, Bill,Sarah Technical Head JacobSmile Assistant Technical Head PratikshaPatil Technical Consultants David,Robert Digital Marketing Manager AlinaSege Assistant Digital Marketing Manager PrashantChevale SME-SMO Executives Manoj, Gemson,Uma Research Analyst EricSmith Circulation ManagerTanaji sales@insightscare.com July,2019 CorporateOfces: Insights Success MediaTechLLC 555 Metro Place North,Suite100, Dublin, OH 43017,UnitedStates Phone -(614)-602-1754 Email:info@insightscare.com For Subscription:www.insightscare.com Insights Success Media and Technology Pvt. Ltd. Ofce No. 22 & 510, Rainbow Plaza, Shivar Chowk, Pimple Saudagar, Pune, Maharashtra 411017 Phone - India: 7410033802,74100058552 Email:info@insightscare.com For Subscription:www.insightscare.com Copyright © 2019 Insights Success, All rights reserved. The content and images used in this magazine should not be reproduced or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, without prior permission from InsightsSuccess. Reprint rights remain solely with InsightsSuccess.

12. BIOLABS: HELPING PEOPLE LIVE A LONGER HEALTHIERTOMORROW Dr. DrewTaylor CEO &Co-founder 10 |July2019|

13. BestHEALTHCARE TO WATCH FOR2019 STARTUPS Achancetoexperiencemorehealthy years with its corn Biolabs is a healthcare technologycompany baseball as a pitcher for both the Toronto Blue Jays andthe Philadelphia Phillies, charting parallel paths across both professional sports andscience. Prior to joining Acorn, Drew spent several years as Chief Science Officer at Epic Capital Management working across the flourishing biotech start-up community. Also, prior to that he was a part of the Mount Sinai Hospital Bioengineering of Skeletal Tissues Team. He has been widely published across international medicaljournalswith specific focus on tissue engineering and sportsmedicine. Story behind theInception It all started when Dr. Drew met Steven Ten Holder and Patrick Pumputis, the other Co-founders of Acorn Biolabs, while Drew was the Chief Science Officer with Epic Capital. Prior to Epic Capital he had been involved with a medical team researching using cell therapy and regenerative medicine for orthopedics. Seeing first-hand how older cells were not as successful as younger cells in replacing cartilage led him to feel there had to be asolution. Meeting Patrick and Steven in many ways felt very much like serendipity as they compared notes. Together they quickly realized that Steven, who had been researching cell division and how technology could be leveraged in longevity; combined with Patrick’s research focus on cell nutrition and preservation; with Drew’s background in emerging health technologies and medical cell therapy. It was all together was a winning combination to create something that could truly change the way people thought about personalhealthcare. Major Challenges on theRoad The regenerative medicine space and all theadvancements around CRISPR, iPSCs, genomics and cell and gene therapy is complicated. Also, consumers haven’t really gotten their head fully around the magnitude of the impact these advancements are going to have in theirlifetime. Acorn is more concerned about the fast-evolving science which is moving faster than consumer understanding ofthe value of their cells. The company believes that one day science will have fully commercialized cell and gene therapy and there will be generations of consumers too old tobenefit. “Acorn has a significant role to play in educating on this space and preparing people for the future. No onethought that today we would be planning for self-driving cars,or focused on giving every human being thebest easy, affordable and non-invasive live cellcollection, • analysis, and cryopreservationservice. • Acorn provides a live cell collection service and a subscription storage model that keeps consumer’s live cells cryopreserved as a healthcare resource for as long as they need it. Preserving live cells also unlocks a vast world of data and genetics on an ongoing basis so that consumers haveinAcornahealthcarepartnerforlife.Acornalsooffers live cell collection, cryopreservation and genetic analysis services. • Why AcornBiolabs? • Acorn Freezes the Clock On YourCells. • The urgency around collecting, preserving and storing youthful cells for future use is real and freezing the clock on your cells today will ensure you can leverage themlater when you need them most. Acorn preserves youryoungest, best cells today to ready you for the future of regenerative medicinetomorrow. • Acorn Unlocks the Future of Regenerative Medicinefor Everyone. • Till now, stem cell collection has been expensive, invasive and painful through bone marrow harvesting, liposuction, blood draws and umbilical cord banking. More recent DNA home testing kits only captured dead cells from saliva that are unusable in cell therapy. Acorn gives a live cell collection that is accessible, affordable and viable for regenerative medicine through the simple non-invasive plucking of a few hairs from your head. This makes the future of regenerative medicine, genetics and powerfulstem cell therapy accessible toeveryone. • About the Passionate and Sporty Leader • Dr. Drew Taylor is the Co-founder and Chief Executive Officer at Acorn Biolabs. Being a Biologist and a former professional athlete, Drew has charted his path across molecular cell biology, science and baseball with steadfast passion over his career. He completed an undergraduate degree in Biology at the University of Michigan and a Masters from the same school in Molecular, Cellular, and Developmental Biology. He also holds a PhD with the University of Toronto in Biomedical Engineering. Drewhas enjoyed a successful career in professional minorleague |July 2019|11

14. Consumers trust us with their cells which as scientists we believe are an invaluable resource that will unlock thefuture their personalizedhealthcare ‘ ‘ 12 |July2019|

16. EMPOWERING Patients throughTechnology Thas facilitatedtheadherence he growing useof The forecasts for the area of technology for health, reaffirm once again an increasingly favorable scenario for engagement and collaboration, through themanagement and sharing of medical data and records. Smartphones and tablets tend to be more and more essential tools in everyday life when it comes to health thanks to applications that providenew ways of accessing information and practicingmedicine. With the consolidation of the use of technology as a tool in daily medical practice, clinics and laboratories specialized in diagnostics have a unique opportunity for relationshipand communication with their patients, allied to the best and most favorable moment for the use of technology in the healtharea. Patient-centered Care Patients wish to get involved intheir health decision-making process, and those who are involved asdecision makers in their care tend to be healthier and have better outcomes. By patient’s journey we understandthe whole process that involves from the moment the patient perceives some symptom or something different in his body, until the completion of thecare. Although the patient’s journey corresponds to all the experience he has from beginning to end in his clinic, the post consultation period ends up being an essential pillar in the construction of this experience. This is because it is at this moment that the patient is able to evaluate the way it has been treated, even analyzing the possibility of a return if he or sheneeds care in thefuture. By following the patient’s journey,you need to think of a model that meets your individual needs and expectations. Therefore, it is possible to understand the need for customization, since no patient is the same as the other. communicationapplications not only of technology focusedon social interactions. Health professionals are much more familiar with the use of technology inmedical practice. Specialized health applications and platforms now take advantage of a global digital model that has come to stay. For some years, information technology managers were askedabout the adherence of health professionals in the implementation of new projects involving technology. Now, through a much more favorable scenario, managers and administrators of clinics and hospitals make much safer and more favorable decisions to such projects. Terms like “Instagram of Medicine” and “Facebook of Physicians” are increasing. Proximity to such applications provides familiarity with an already consolidated interactionand navigation model, preserved in due proportions. 14 |July2019|

17. Tech-spotlight ABOUT THEAUTHOR Dimas Francisco Silva Jr, Medcloud Founder andCEO,aHealthentrepreneur,believesinthe powerofcentralizeddatafordecentralizedcare. He has mission to accelerate the transition of imagingcenterstotheCloudandispassionate about Patient Experience, A.I and Medical Networks. Medcloud is an All-In-One platform for diagnostics management, EHR RIS, DICOM Viewer, Drive Storage, Portal of Diagnostics, 100% Web frrom Diagnostic Imaging Centers, Telemedicineprojects,andDentalCompaniesto Cardiology Centers. A common challenge is managingtheinformationofpatientsandtheir exams,inasecureandreliableway.Morethan just increasing productivity, Medcloud offers timely and uncomplicated solutions for the entirelifecycleinhealthcaredatamanagement. DimasFranciscoSilvaJr Founder andCEO Chronic patients, for example, face somewhat different journeys. By necessity of monitoring, these people need to have a much greater controlof their medicalinformation. Someone who needs to visit their doctor regularly, gets stuck to numerous images and physicalreports. When a diagnostic center offers other options, such as outcome portals or applications for storing these exams, it engages itspatients. A person who goes from a reality of having to organize, store and carryto having all the information gathered from a click gainsempowerment. By fostering digital services thattake advantage of new, mobile Internet access, providers are beyondengaging their audience, facilitating the Physician-Patient relationship, since such devices have revolutionizedthe way wecommunicate. It is also important to consider the whole group of family and friends around the patient. Often, the caregiver is not active. So there is the concept of engaging people to consider everyone around the patient and take a more active role. It is important to includeall thesesubjects. By bringing the diagnostic industry closer to the digital trends of the market, mobile devices like smarthphones and tablets appear asthe first choice of relationship. Inaddition, offer even more options to put the patient in control, such asscheduling appointments and exams, sending some documents, and small tasks that facilitates their daily lives,approaches thepatient. Technology plays a key role in strengthening the doctor-patient relationship. Providing channels of communication and more practical ways for the patient to be able to ask questions or, eventually, to ask forhelp from their specialists also puts the patient in a more activerole. Leave the patient in the position of control of their own health. Giving flexibility, convenience andpracticality in the age of the internet and mobile devices is not a differential, it is the minimum that any clinic or hospital can offer itsclients. |July 2019|15

18. BabyMed Healthy Mothers, HealthyBabies Baccesstoreliablematernalandchildhealthcare “ abyMed is an integrated and innovativemobile health platform that provides easy andaffordable We wish to create aworld informationandservices.Theplatformprovidesimportant where no woman shoulddie weeklyhealthmessagestopregnantwomen,motherswith newborn babies, and their family members. It comprises of SMS text messages, voice messages, Interactive Voice Response(IVR)onwebinformationportal. The major aim of BabyMed is to empower pregnant women and their partners to take the steps necessary for a healthy pregnancy and safe delivery. The SMS text and voice messaging service integrates all the healthy pregnancy and safe motherhood topics under one platform. This includes earlyandcompleteANCattendance,malariaprevention,the preventionofmothertochildtransmissionofHIV(PMTCT), individualbirthplanning,andsafedelivery. OutstandingMission In African nations (Kenya in particular), 6000 women die every year due to preventable pregnancy or childbirth problems. The doctor to patient ratio in Kenya is 1:17,000 (WHO recommends 1:1000). Due to a lack of collective community knowledge for safe and healthy pregnancy and 75% of the Kenya population living in the rural areas, pregnant women and mothers may delay seeking care or takingappropriatepreventativeorcurativeaction. Toresolvethissituation,BabyMedisonamissiontosavethe lives of the 6000 pregnant women, guardians of young children,andwomenofchild-bearingagewhodieeveryday in Kenya due to preventable pregnancy or childbirth problems. AbouttheCompassionateLeader Bryan Okello, the Founder/CEO is a highly motivated, passionate, and result oriented professional. He has a keen interestonengaging,developing,andimpactingcommunities through information communication technologies to deliver highly effective and creative solutions to businessand while bringing life to thisworld and every child born should grow to realize its fullpotential “ technologychallenges.Bryanhasbeeninaccounting,finance and business information technology, hands-on software training,andwebdevelopmentformorethantenyears. Bryan is passionate about transforming maternal and child health care in Kenya and in Africa through the utilization of mobile and digital technology. His inspiration for comingup with BabyMed is the desire to see a world where no woman should die while bringing life to this world and every child bornshouldgrowtorealizeitsfullpotential. UniquenessatitsBest BabyMed provides age and stage-based messages aligned with global best practices, empowering women to make the bestdecisionsforthemselvesandtheirfamilies.Thecompany leverages the high number of mobile devices to inform and empower mothers to adopt healthy behaviors and to access maternal and child health services. With increased access to high quality, relevant local health information, mothers and families would demonstrate improved health-seeking and preventative behaviors, including uptake of antenatal care, early care-seeking in response to childhood illness, hand washing, cord care, etc., that should ultimately contribute to improvedmaternalandchildsurvival. Besides,BabyMed’sSMSandaudiomessagesaretargetedto awoman’sstageofpregnancyortheageofherchildsothat 16 |July2019|

19. BestHEALTHCARE STARTUPS TO WATCH FOR2019 BryanOkello Founder &CEO |July 2019|17

20. theinformationreflectsexactlywhatsheisexperiencingata particular time. This helps to build an emotional connection withthemotherandasenseoftrust,makingitmorelikelythat she will be receptive to messages that encourage changes in behavior. The messaging program accompanies eachmother onherjourneyoflearninganddiscoveryandactsasastep-by- step guide to a healthy pregnancy and a healthy baby. BabyMedprovidesICTconsultancy,innovativesolutionsfor theeducationsector,andwebdesignanddevelopment. • Talkingaboutsocialactivities,thecompanyconductsTwitter chats on maternal and child health issues and also organizes marathons (Beyond Zero marathon) and walks targeted at highlighting maternal and child health mortality. Not only this, but BabyMed also advocates and promotes exclusive breastfeedingforchildrenaged0-6months. • Awards andRecognitions • Top application in the health category in the Safari.com appdeveloperchallenge • TopTenFinalistintheWomen&AccesstoHealthCall for Initiatives! In April 2019, Bryan Okello was shortlisted as one of the top ten finalists (the only finalist from Africa) in Women & Access to Health Call for Initiatives!OrganizedbytheWomen’sForum. • Publication of BabyMed’s story in the StartUpHealth Magazine • Partnership with StartUp Health. In June 2016, BabyMed was selected by StartUp Health to joinits Portfolio of Digital Health Companies working to transform Health Care with Bryan Okello becoming the First Healthcare Transformer from Africa to join the academy. This was a very important milestone for the company because guidance from StartUp Health and access to its networks will be crucial in accelerating our growth. StartUp Health is leading a global movement to transform health by organizing and investing in the world’s largest community of Healthcare Transformers. With the coaching, support and promotion from StartUp Health Academy, BabyMed is now well placed to transformmaternalandchildhealthcareinKenya. • shouldrememberthatlearningisacontinuousprocess. • Secondly,itsuggeststoThinkSmall,AtFirst.Astheworldof healthcare is very much regimented, innovation may be something completely world-changing in time, but at first, oneshouldfocusongettingitadoptedonasmall-scalebasis whereitseffectivenesscanbeproven. • Lastly,itrecommendstoGetOutTherebecausethecompany believes that spending as much possible time in the exact environment the product will be used in, will give an ideaof thenuancesandpotentialissuesthatwillcomewithitsuse. • StrategicPlanforaGloriousFuture • Signuponemillionusers • Translation of messages to local languages such as Kiswahili,Kikuyu,Luo,Kamba,Kalenjin • Set up BabyMed Social: An interactive social network where mothers can read articles and have a conversation withtheirpeers • Set up BabyMed on USSD in order to offer weekly two interactivequizzestailoredtomothers’gestationalstageor theageoftheirbaby • Expand to other east African countries such as Tanzania, Uganda, and Rwanda. Institute a monthly block knowledge sharing sessions that bring together all expectant mothers registered at a facility for information sharinginagroup. • Set up Maternal Health Corners with partnering health facilities made up of a set of computers that have been programmed with content (audio, video, and text) forthe benefitofhealthworkers • What’snextintheStore? • BabyMedwouldbelaunchingitsandroidmobileappaswell asitsredesignedwebsite.Thecompanywouldbesigningup partnership agreement with Uridu.org. URIDU is a non- profit,non-partisanorganizationthatempowersruralwomen indevelopingandemergingcountries.Also,discussionsarea in an advanced stage to partner with ‘Africa’s Talking’ to facilitatescaleupofitsmobileservicetoallpartsofKenya. Three-pieceAdvice BabyMedadvicesthebuddingentrepreneursinthehealthcare space to Anticipate Potential Snagsi.e. every meeting is an opportunity to develop and grow. No doubt, there will be somemistakesalongtheway,butiftheycan’tbeavoided,one 18 |July2019|

22. 5 HEALTHCARE STARTUPS ARTIFICIALINTELLIGENCE AI in medical technologies is doing miracles in the healthcare industry. It can easily process huge data, help in diagnosis and provide accurate results. AI comeshandyasitspeedsuptheresearchandanalysis of various processes including drug discovery and geneticmodifications. IOMT Internet of Medical Things or in common language healthwearablesareboomingallovertheworld.Due to its effectiveness towards keeping oneself fit, ithas been on the top for a long time now. The most beneficialpartofIoMTisitcanbeconnectedthrough various mobileapps. 20 |July2019|

23. Tech-trend TELEHEALTH With evolving technology, healthcare has moved on as well. With the help of various techniques, it has now become possible for doctors, hospitals to providetreatmenttopatientsremotely. DATAANALYSIS Dataanalysisisnothingbutadigitalorganizerthatwill also perform analysis processes like health records, lab results, medical history, diagnosis history, and many more. It has been saving precious time and manpower. VR/AR Virtual Reality or Augmented Reality has already taken overthetechnologiesofallthesectors.But,specifically, speaking about healthcare, it has been doing wonders. From diagnosis to medical education, VR and AR have helpedthissectorflourish.Ithasbeensaidtobeusefulin providingtreatmenttoawiderangeofillness. |July 2019|21

24. BiomeAnalytics Clinical Performance Solutions for High-performing CardiovascularCenters Cboth men and women. Hospitals and doctors ardiovascular disease affects over 11% of theUS population and is the leading cause of deathfor treating these patients face unprecedented challengesdriven by increasing volume, disruptive new procedures, greater competition, and the transition to value-basedcare. Successfully confronting and succeeding over these challenges require providing clinical and administrative teams access to trusted data and clinically and financially relevant insights. But, because cardiovascular care ishighly nuanced, one-size-fits-all analytic solutions lack the precision required to engage clinicians and cannot show users how to improve. Internal analytic teams are stretched thin, lacking deep expertise in the cardiovascular and cost accounting domains, and struggle to stay au fait with changing standards of care, best practice guidelines, and reimbursement models. In an effort to help providersand “ Our unique solutions combineadvancedanalytic techniques with human- driven insights to help hospitals and doctors at leading heart centers be theirbest administrators solve these issues, Biome Analyticswas formed. In 2013, a team of data scientists, engineers, and clinical experts came together. They all had a common goal of providing doctors and hospitals with the granular insights necessary for improving care and lowering costs for over27 million Americans with heart and vasculardisease. Stuart Jacobson, the CEO of Biome Analytics, founded the company believing that if a common fact base for performance management existed, doctors and hospitals would self-optimize in delivering high-performance cardiovascular care and excellent quality clinical care atthe lowest possible cost. “We specialize because cardiovascular care is unique, sometimes variation makes sense, and generalized tools and analytics have failed to engage and align clinicians,” saysStuart. “ What does Biomedo? Founded in San Francisco, California, Biome Analytics isa cutting-edge leader in the digital healthcare space. The company delivers a new generation of clinicalperformance applications that bring hospitals and doctors together around a trusted data source, clinically relevant benchmarks, and actionable insight. The company was established with the guiding principle- ‘Every clinician wants to deliver the best possible care’. Secondly, it also believes that ‘When the clinicians have trusted, actionable insights, they will self-optimize.’ 22 |July2019|

25. BestHEALTHCARE STARTUPS TO WATCH FOR2019 StuartJacobson CEO |July 2019|23

26. Biome provides the ability to the hospitals and doctors to seamlessly align around how to , eliminating expensive guesswork around what specific actions will move thecost needle, and providing clinicians the tool they need toshow exactly when care variation isnecessary • WhyBiome? • IntelligentVariation • Biome has procedure-specific performance modelsthat seamlessly integrate hospital cost accounting and clinical data. Its algorithm-based performance assessment engine detects high-value clinical and financial opportunities for clients. Biome delivers a community-driven performance library, containing clinical and financial benchmarks, models, and performance improvementstrategies. • Cardiovascular Focus andExpertise • Biome’s applications enable hospitals to increase contribution margins throughout the cardiovascular service line. Clients rely on Biome’s experience to evaluate the impact of evolving therapies, identify vendor opportunities, and quicken time to value. Some recent client successesinclude: • $2 million cost savings opportunities identifiedwithin 60days • Average TAVR LOS reduced by 3days • Net-new 164 bed openingavailability • $1.7 million in cost misallocationidentified • Observed vs. Expected Mortality Decreased by35.7% • A Delivery Model Built for Speed and Quality While analytic applications largely focus on IT departments as the primary user, Biome focuses on delivering analytic capabilities to the physicians and administrators, without requiring users to becomedata scientists. Additionally, Biome manages the full engagement- from requesting and collecting data, to creating the models, to delivering the insights. Users can ask questions and get answers in record time. Finally, with access to a library of over 200+ cardiovascular-specific analytics, clients can explore a myriad of improvement opportunities in seconds, instead of waiting for weeks for the internal teams to create a newanalytic. Biome’s UniqueSolution Biome offers an end-to-end solution for cardiovascular performance management; over 200 cardiovascular-specific analytics that drives the insight into actionable root-cause performance improvement opportunities. Analytic access is provided to users via Tableau visualizations, and Biome’s engagement team highlights high-value opportunities, besides delivering insights into performance change management progress. Biome approaches engagements with the philosophy that analytics should augment thework of cardiovascular teams, not replace physicians’ decision- making autonomy. Biome provides the analytics thatallows physicians to understand the cost impacts of decisions and the case studies and change management methodologiesfor affecting performance improvement at clientfacilities. Biome delivers performance bench-marking so that cardiovascular teams can measure progress bothinternally and against other cardiovascularcenters. Advice to Digital HealthEntrepreneurs Today, as healthcare decision-making becomes much more nuanced and complex, Biome advises the budding entrepreneurs in this field to stay focused and have an unwavering vision. The company believes that healthcare is a ‘team sport’ and each participant in the industry, whether an entrepreneur, clinician, administrator, orpatient, rely on the others to achieve success. It also believes that collaboration and communication are crucial to asuccessful team and these capabilities bind the team with motivation and positiveapproach. LookingForward Biome’s distinctiveness is a breakthrough value-add for cardiovascular teams providing noticeable clinical and financial impact. Clients have appreciated the company’s responsive services and analytic solutions. Talking about the accolades received by the company so far, Stuart asserts, “Our happy clients are our greatest award—when we see the success that they achieve as a result of our solution, we are motivated to develop even more modelsto improve cardiovascularperformance.” Biome Analytics is focused on developing solutionmodules in cardiovascular-related clinical areas such as stroke, vascular, and neurology and is planning to roll these out to all clients thisyear. 24 |July2019|

28. ConversaHealth Enhancing Communication, BuildingRelationships, and Revamping the CareExperience M “ eaningful doctor-patient communicationis central to effective patient caremanagement. Conversa enables healthcare organizationsto monitor, manage and communicate with their patients more effectivelyat scale than everbefore Not only does this enhance thepatient experience, it also helps encourage the patient to bea more collaborative partner in their care. Today’spatients expect transparent and timely flow of information, for themselves as well as their loved ones. Developing a personal and compassionate relationship with patients has been a crucial role to play in the success of healthcare providers. Conversa Health, an emerging digital healthcare company, helps make the process of building long-lasting relationships with the patientseasy through its innovative technology - The Conversa Conversation Platform™. Conversa is transforming healthcare from episodic experiences to a continuous and personalized relationship. By personalizing and automating care communication, it envisions to make conversationa cornerstone of the healthcareexperience. Proven Experience and Passion West Shell III, CEO and Co-founder of Conversa,has been a catalyst to the company’s fast-paced growth. A 5-time start-up CEO and the son of a real-estate entrepreneur, Shell is a creative and enthusiastic leader. He has a background in business strategy and an impressive track record of building high growth, innovative companies with world-class employeesand “ committed customers. His extensive experience marks him unique in the crowd of digital health innovators,and has helped him accelerate the company’s growth. With his business acumen and expertise, Shell raisedsufficient funds from the right sources, partnered with the right people, and is leading Conversa’s path ofsuccess. Conversa is the brainchild of Shell and hispartner Dr. Philip Marshall, the Co-founder and Chief Product Officer of the company. Although these twoare the creators of the company, Conversa owes its success to a few prominent team members: Chris Edwards,the 26 |July2019|

29. BestHEALTHCARE STARTUPS TO WATCH FOR2019 West ShellIII, CEO &Co-founder |July 2019|27

30. Chief Client Experience & Marketing Officer, Murray Brozinsky, the Chief Strategy Officer, Becky James, Vice President of Operations, and ToddGrant, Vice President of Finance and HR. This is a unique group of dedicated healthcare professionals and technologists who are passionate about transforming the healthcare experience through automated, personalized patientconversations. Where it allstarted? Conversa is influenced by Shell’s personal life experience. He grew up with three sisters, all of whom suffered from several chronic health conditions that needed continuous monitoring. “My three sisters are the ones who drove me to create Conversa. In each case,the health system failed them. They did not receive the educational materials and personalized information to help them manage their conditions,” Shell said. “Once they left the clinical encounter, they stopped being patients.” Unhappy with the conditions that his sisters faced, Shell realized there was need for effective communicationand continuous monitoring of a patient’s health in order to deliver better care. The will to improve the healthcare communication process is the spark that drove him to build ConversaHealth. Conversa ConversationPlatform™ As healthcare’s conversation platform, Conversadelivers an easy and meaningful way for care teams and patients to communicate. It has an extensive library of over 700 clinically-intelligent conversation programs that include asthma, chronic obstructive pulmonary disease (COPD), congestive heart failure (CHF), diabetes, hypertension, joint replacement, and many more. The company offers innovative and scalable Conversational AI technology enabling healthcare organizations to deliver automated, personalized doctor-patient conversationexperiences. The improved scale and communication leads tomore meaningful patient relationships, effectivepopulation management and, ultimately, better clinical andfinancial outcomes. The Clinically-intelligenttechnology Conversa’s proprietary technology, which includes a taxonomy-driven patient profile, automaticallycalibrates the timing, channel of outreach, priority, and sequencing of modules for the conversation content delivered. Over time, Conversa’s smart technology learns and identifies profile-based patterns that dynamically adjust and improve what is asked, what is said, and what data is collected from each patient in each conversation. This feature allows the care providers to engage and monitor the patients individually. No two conversation experiences are alike because no two patients arealike. IllustriousAcknowledgments In its journey so far, Conversa has received manynotable awards and accolades for its valuable contribution to the healthcare industry and best-in-class product. This includes the honorable recognition as Digital Health Disrupter and Leader in a research report published by Juniper and the North American Patient Engagement Solutions Technology Leadership Award by Frost and Sullivan. The company was also chosen as an IDC Patient Engagement Innovator, a Leading Care Management Virtual Health Assistant by HealthXL, and a Top Patient Relationship Management Solution by ChilmarkResearch. What’sAhead? More and more health organizations and healthcare technology companies are using Conversa: Northwell Health, Atrium Health System, University Hospitals, Centura Health, Healthgrades, Allscripts, and many more. As Conversa is well positioned to engagemassive populations on a personal level, the company is also receiving tremendous interest from Pharma and Payer organizations looking to engage patient users to drive lower costs and improve healthoutcomes. 28 |July2019|

32. Micrima A Leading Organization DevelopingTechnology for Breast CancerScreening “ Our major mission istoreduce the number of womenwho die of breast cancer bydeveloping a system that can aid earlier detection of thetumor Tinsize is detected, with no lymphinvolvement, oday, over half a million women die ofbreast cancer every year. Yet, if a tumor of less than1cm survival rates at 5 years are comparable with someone who has not had cancer. Addressing this problem, an eminent organization named Micrima was set up with the aim of reducing the number of women who die of breast cancerby developing a system that can aid earlierdetection. Micrima believes that the early detection of breast cancer can be achieved by frequent screening from an early age, which cannot be achieved with current screening methods. Dedicated to improve the conventional diagnosis methods, Micrima has set out to develop a system that iscomfortable for the patient, easy to interpret, and can be usedfrequently from a much younger age in order to detect cancerearly. Originally based on technology for the detection ofburied landmines, the early application to breast imaging was spun-out from the University of Bristol, as Micrima, in 2006. The founders of the company, Roy Johnson, Professor Alan Preece, and Professor Ian Craddock, recognized the impact the technology could potentially have on breast cancer detection and mortality rates. Until 2014, Micrima continued to fund the work at the University, when the reduced technology risk justified the investment into establishing and growing the physical company. Today, the company consists of 23 hardware, software, and product development engineers with asmall commercial team. It is continuing to expand in all areasof the business to meet the strategic aims of thecompany. “ conversant with bringing complex technologies to market, developing worldwide distribution networks, and negotiating and managing strategic relationships with some of the industry’s leading players. Following a career inlarge USA corporates, he has founded 4 medical technology companies and has advised the government in the Life Sciencessector. MARIA®: A Unique Product ofMicrima MARIA® (Multistatic Array Radio-wave Image Acquisition) is a revolutionary product of Micrima that uses radio-waves to detect breast cancer. The procedure of diagnosis includes the patient lying on their tummy on the bed, such that breast to be imaged is pendulant through a hole in the bed. Then, the array comes up to meet thebreast, there are different size inserts to accommodate different sizes of breast. This array contains 60 antennae that each transmits and receives. They each do this in turn, taking 22 seconds before the array rotates. The same process is repeated twice more to build up a 3D map of the tissues throughout the breast. MARIA® measures the signal reflected at the interface between tissues of different electromagnetic material properties showing reflections from the edges oflesions. The commercial team at Micrima is working very closely with its clinical partners ensuring the exact needs of the customer are met. Today, MARIA® is used as an adjunctto About the Intellectual Leader Roy Johnson is the Executive Chairman of Micrimawho has over 35 years’ of enriching experience in the medical device and diagnostics sector. He has been operating at board level in both the UK and the USA. He isparticularly 30 |July2019|

33. BestHEALTHCARE STARTUPS TO WATCH FOR2019 Roy Johnson ExecutiveChairman |July 2019|31

34. other imaging modalities to reduce the chances of missing the tumor. Producing the image takes about 1% of the collected data on the breast tissues, so there is a lot more information available. The next important step is to work with the clinical partners in Europe to understand what information they require and the best way to display such information, adding higher levels of functionality to the system. The company will launch the first step of this program soon and will begin to classify regions of interest as to the likelihood of these regions of interest beingbenign ormalignant. Professor Lain Lyburn, a consultant radiologist at Thirlestaine Breast Centre, Cheltenham, recently said,“We have been involved in the evaluation of the MARIA® system for some time now and whilst it is currently offered as an adjunct to other imaging modalities, particularly where dense tissue is involved, the technique promises theexciting ability to distinguish between tissue types in the future. Any imaging modality that can readily give this sort of functional information has the potential to influence many points in the diagnostic and treatment pathways - there could be less need for biopsies and possibly a reduction in overtreatment.” Challenges on the Way The road to success is never easy. Likewise, Micrima,faced many ups and downs in getting to this stage of development. Right from persuading the investors to back the growing enterprise to solving various technical challenges along the way and ensuring the right approachto the commercialization of the product, Micrima has overcome all thesehurdles. On the financing front, though it wasn’t tough forthe company to convince the audiences of the unmet need regarding breast cancer, the case still had to be made for its specific technological approach. The crucial part was to prove the capability and determination of the keypersonnel and the growing management team. Today, Micrima is supported by a growing list of quality investors who passionately wish to take the organizationforward. Awards andAccreditations In recent years, Micrima has been recognized with several awards. Most of these awards are focused on thetechnology and innovation of the MARIA® system. These include general innovation awards, like the ‘Medilink SW innovation Award in 2018’. Micrima has also been honored with ‘The Frost and Sullivan New Product Innovation Award- Breast Imaging in 2019’ and the ‘Global Healthand Pharma Best Oncology Diagnostic Imaging Device Manufacture in 2019Award’. Moving towardsSuccess The ongoing primary goal for Micrima is the evolution of the MARIA® software to deliver increasing degrees of tissue differentiation. The company is hopeful to be able to identify the type of malignancy along with the diagnosisof the disease. “If we can assist radiologists by indicating which are low grade, slow growing, and can/should be monitored over time, and which are invasive, high grade, and rapidly growing, this could have huge implications for the treatment of breast cancer. There is also the possibility to use this technology for detecting other types of cancerin the body in the future,” saysRoy. On the commercial front, Micrima will continue its progress in Europe. The company is also planning totake this inventive technology to the US and Asia, once the relevant regulatory approvals are inplace. 32 |July2019|

36. NEMAURAPHARMA Offering Precise User-friendlySkin-based Drug DeliveryTechnologies “ Ndelivering drugs through the skin.Today, it is a We focus on innovation,not emaura Pharma is a renowned organizationthat started with developing a single technologyfor just to create newdrugs or medications, but also tomake the existing healthcare systemsbetter. company with over 100 patents filed, many of whichare already granted in multiple territories. The patents cover a diverse array of platforms that allows the administrationof almost any drug through theskin. Today, the company is at the forefront of Transdermaland skin drug delivery having developed in-house specialist knowledge and skills, and multiple proprietary novel delivery systems. The company is well positioned to provide solutions for complex drug delivery challenges, using an array of formulation and devicetechnologies. “ About the Ingenious Leader Dr. Faz Chowdhury, the dynamic Founder and CEO of Nemaura Pharma originally trained as a drug formulator, and also holds a Master’s degree in Microsystems and Nanotechnology from Cranfield University in the UK, anda PhD in nanomedicine and drug delivery from theUniversity of Oxford. So, far he has amassed over 100 patents across over 20 technology platforms as sole inventor, as well as having written textbook chapters for Wiley and Elsevier on the subject of Bio-Nanosciences. Apart from Nemaura Pharma, he also founded Nemaura Medical Inc., which is a public listed company in the US (Nasdaq: NMRD), focused on developing and commercializing non-invasive wearable diagnosticsystems. InspiringJourney Prior to commencing studies at the University, Dr. Faz had always planned to start his own technology company that would give him something challenging to pursue. Initially, the hard part for him was to decide when to set up a company and in what field. During his undergraduate studies, he discovered his strength in drug formulation and delivery systems. Within his first eight years ofemployment he decided that it was the right time in terms of experience and exposure in the industry, to set up NemauraPharma. InnovativeServices Nemaura started with a single technology for chronotherapeutic drug delivery. Today, it has grown to become a leading expert in the field of drug delivery through the skin with multiple proprietary platform technologies covering injectables, topical, andtransdermal formulations and over 21 drugs in the active development using these platforms covering a wide range oftherapeutic areas. Nemaura takes pride in being able to undertake complex drug delivery challenges and developing both formulation and device based solutions to tackle these challenges. The company has in-house facilities to be able to design develop, test and manufacture prototypes of devices and drug formulations. It offers comprehensivepharmaceutical formulation development services from concept to clinical batch production and supply, all based on its proprietary intellectualproperty. 34 |July2019|

37. BestHEALTHCARE STARTUPS TO WATCH FOR2019 Dr. FazChowdhury Founder &CEO |July 2019|35

38. Today, as with most of the technology companies andmore so for companies working in the Pharmaceutical domain, getting a first product to market could take over a decade. There is a continuous cycle of bringing in new investment which is no mean feat for any company as the criteria for the investment is the same no matter how small or largethe company. Nemaura has seamlessly navigated this situation with its compelling technology platforms and has raised substantial funds both through product licensing as well as from equity investors. Currently, the company is poised to make some radical changes in the field of drug delivery in particular and to the field of biologics and vaccines, which collectively addresses a market opportunity in the 10's of billions ofdollars. field with vast potential for innovation. Innovation in this field does not necessarily have to be related to new medicines and therapies, it can also be methods anddevices to make existing medicines easier to administer and perhaps with enhanced safety profiles through drug targeting or a change in the route ofadministration. Companies should find a specific problem to solve andput resources and effort into developing a practical and cost- effective solution to that problem so that there is a clear route to market, preferably built on clinical need, and if it can then be applied to other drugs is then that is a bonus, rather than starting with a platform technology at the outset ” advises Dr. Faz to the buddingentrepreneurs. He further adds, “Finally, we can’t be phased by the long lead times to develop and bring a technology or productto market, which can in the case of a new drug delivery technology over 10 years; if the technology has real tangible benefits to the patient and the potential to reduce the burden on healthcare providers then it is worth pursuing.” Future Prospect One of the breakthrough technologies of Nemaura allows proteins and vaccines to be produced as a solid dosage form, in the form of a small particle or microneedle like structure. The company has spent almost six years perfecting this technology and securing intellectualproperty around it. The company has a very ambitious goal of adapting multiple vaccines in to this technology platform as it offers two fundamental advantages: the first is that it avoids the need for having to store the drug in a refrigerator prior to use, and so reducing the cost of the cold chain maintenance. The second advantage is that it is very easy to use and can be self-administered without anytraining. The company has estimated that this project would require up to a decade to fully execute. Within the next 5 years, Nemaura expects the bulk of over 21 drugs indevelopment to also be launched in to global markets, including drugsto treat migraine, osteoporosis, and diabetes. Nemaura is currently also planning to build its own state-of-the-art research, development and manufacturing facility in Loughborough, UK. ColossalAchievement When asked about the milestones the company has achieved so far, Dr. Faz shared, “Early in the company’s history we embarked on a development program for a complex transdermal patch, and within 3 months we completed initial proof of concept and subsequently wenton to successfully develop the product through to clinical trials and submission to the FDA (United States Food and Drug Administration).” This was a highly challenging formulation with some serious intellectual property constraints to navigate. There were few companies including multinationals that were able to successfully develop this product at the time. It was a mammoth achievement for the company’s scientists and engineers, reflecting on their ingenuity andexpertise. Awards andAccolades Nemaura received the ‘Frost and Sullivan Technology Leadership Award ’ in 2016 for Europe for its cutting-edge innovative skin delivery technologies and for its potential impact in the future for the administration of a wide range of medicines. Last year, in 2018, the company alsoreceived the ‘Medilink UK National Award ’ for drug delivery which was further endorsement of its innovativetechnologies. Words ofAdvice “The healthcare space is and will always be aburgeoning 36 |July2019|

40. TransformativeAI Revolutionizing Healthcare with DeepLearning Aof chronic diseases isTransformativeAI.The “ n eminent start-up that createsartificial We believe that withAI,we can transform healthcare workflows and save lives while generating value for patients, health systems, andsociety intelligent algorithms to predict acuteoutcomes start-up’s vision is to develop a suite ofAI-enabled predictive analytics for a wide range ofmedical conditions. A UniqueApproach Today, globally, over six million people per year suffer from Ventricular Tachyarrhythmia (VT), which is a precursor to Sudden Cardiac Arrest (SCA). There is no existing cardiac monitoring technology that can automatically and accurately warn healthcare providers of an oncoming arrest. Instead, bystanders or healthcare providers rush to begin delivering cardiopulmonary resuscitation (CPR) and if possible, prepare for defibrillation. Transformative AI is aimed at changing this scenario and with this goal, the start-up has itsinitial focus on predicting Sudden Cardiac Arrest (SCA)before itoccurs. Using advanced AI and statistical analysis techniques from Cambridge University and CERN, Transformative AI’s algorithm detects minute changes in patient physiology and predicts an imminent real-time risk of SCA. The unique algorithm would serve as the basisfor an early warning system that would improve patient- survival for a broad spectrum of high-risk patients.This approach maximizes the time for clinicians to provide timely defibrillation, providing patients with the best chance of survival and creating a step change in the rapid-responseworkflow. “ Furthermore, predictive monitoring holds the potentialto prevent ventricular tachyarrhythmia (VT) from developing in a subset of patients. Thus, early warning can usher in a new era of research into the use of antiarrhythmic medicines to prevent SCA. The company’s second wave of products will build upon its initial work by improving care for related cardiac conditions. Transformative AI believes that AI will generate massive value when it is used to transform healthcare workflows. About the Trio Dr. Marek Sirendi, one of the Co-founders,previously worked as a data scientist on the Large Hadron Collider at CERN, where he performed the world’s most precise measurement of the W boson and designed real-time decision algorithms for LHC collisions. He holds aPhD 38 |July2019|

41. BestHEALTHCARE STARTUPS TO WATCH FOR2019 Dr. MarekSirendi Co-founder |July 2019|39

42. in Physics from the University of Cambridge and was a Marie Curie fellow. He co-founded the company with Dr. Joshua Oppenheimer, who is an Emergency Medicine Physician, and Dr. Marek Rei, who is a lecturer in the Department of Computer Science at the University of Cambridge. Dr. Rei is a deep learning and predictive analytics expert from his work at SwiftKey, a company that created a predictive keyboard and exitedto Microsoft. Exceptional Algorithm for theBetterment Transformative AI’s artificially intelligent predictive algorithm, CodeRhythm, predicts SCA within minutes, with high accuracy on cardiac data. This would serveas the basis for an early warning software-as-a-servicethat would alert clinicians of impending ventricular arrhythmias and improve patient survival acrossvarious global healthcaresettings. Awards andAccolades Transformative AI has won competitive public and private award funding in the U.K., EU, and the U.S.It has also won the Global Pistoia Alliance Audience ChoiceAward. The company was one of the first start-ups to work with the Center for Medical Interoperability in the US. Itwas also selected to work with Philips Healthworksand Entrepreneur First and was named as ‘ TechCrunch’sTop 3 Entrepreneur FirstStart-ups’. Turning Challenges intoOpportunities Asked about the major challenges they faced while launching the start-up, they said, “As the predictive healthcare field is so new with few precedents, we’vehad to work with and will continue working with several regulatory consultants and lawyers.” As a healthcare start-up, Transformative AI hasachieved more than its share and will be looking forward to more advancements and developments. Upon asking them about what advice they would give to budding entrepreneurs, Dr. Sirendi said, “Stick with your goal and never give up.” 40 |July2019|