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A Pivotal Advance in the Global Fight Against Tuberculosis

Tuberculosis (TB), an enduring global health threat claiming millions of lives annually, has encountered a breakthrough at the Indian Institute of Science (IISc).<br>

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A Pivotal Advance in the Global Fight Against Tuberculosis

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  1. A Pivotal Advance in the Global Fight Against Tuberculosis

  2. The Global Challenge TB remains a significant global health challenge, particularly in countries like India, where 2.7 million people fall ill each year, resulting in over 400,000 deaths. Drug-resistant strains, prolonged treatments, and health tolls make TB a formidable adversary, necessitating innovative solutions. Unlocking Mtb’s Secrets tilising cutting-edge tools, IISc researchers delved into the intricate workings of Mtb, revealing the previously undiscovered gene, whiB7.

  3. WhiB7 as the Bacteria’s Vital Component The significance of whiB7 lies in its role in facilitating Mtb’s “hibernation” within human cells, enabling the bacteria to persist and cause chronic infections. Targeting WhiB7—A Novel Approach Under the leadership of Dr. Ayesha Khan, the IISc research team proposes a groundbreaking approach to develop drugs specifically targeting whiB7, referred to as “host-directed therapy.”

  4. Personalised Medicine on the Horizon The concept of host-directed therapy targeting whiB7 opens the door to a new era of personalised medicine in the field of tuberculosis treatment. Tailoring treatments to the specific genetic vulnerabilities of individuals could potentially result in more efficient and less invasive interventions. Ethical Considerations and Access to Treatment As the scientific community moves forward with the development of whiB7-targeting drugs, it is essential to consider ethical implications and ensure equitable access to these potential therapies

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