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Animal Models in Immunology

Animal Models in Immunology. Adam Brown and Teresa Fulk. Nude Mouse. Discovered in 1962. Is hairless, and more importantly, lacks a thymus. Homozygous for recessive trait called “nu” Immunodeficient since it can’t produce T-cells and lymphocytes.

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Animal Models in Immunology

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  1. Animal Models in Immunology Adam Brown and Teresa Fulk

  2. Nude Mouse • Discovered in 1962. • Is hairless, and more importantly, lacks a thymus. • Homozygous for recessive trait called “nu” • Immunodeficient since it can’t produce T-cells and lymphocytes. • This allows for implantation of human tumor cells into mouse without rejection.

  3. Scid Mouse • Def. “A laboratory animal that, lacking an enzyme necessary to fashion an immune system of its own, can be turned into a model of the human immune system when injected with human cells or tissues.” • Discovered in 1983. • S.C.I.D. – Severe combined immune deficiency • Found to be more immunodeficient than nude mice • Used as a blank slate immune system. • Used in oncology, immunology, infectious disease, rejection of tissue transplants.

  4. Transgenic or Knock-out Mouse • Mouse that has DNA artificially transmitted into it. • Are produced from genetically engineered embryos. • Through breeding, strains of mice created with desired traits.

  5. References • http://www.immunecentral.com/immune-system/iss29.cfm • http://www.vetmed.ucdavis.edu/Animal_Alternatives/cancer.htm • http://home.comcast.net/~john.kimball1/BiologyPages/N/NudeMouse.html • http://darwin.bio.uci.edu/~tjf/tmf_tgms.html • http://www.uac.arizona.edu/VSC443/rodentmodels/rodentmodel06.html • http://www.accessexcellence.org/RC/VL/GG/transgenic.html

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