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Schematic representation of biochemical markers of bone remodeling

Schematic representation of biochemical markers of bone remodeling. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 11 5059-5075. Shengai Li’s thesis. Serum osteocalcin level. Higher OC what’s that mean?.

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Schematic representation of biochemical markers of bone remodeling

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  1. Schematic representation of biochemical markers of bone remodeling The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 11 5059-5075

  2. Shengai Li’s thesis

  3. Serum osteocalcin level

  4. Higher OC what’s that mean? Osteocalcin: Osteocalcin, or bone gla protein, is a noncollagenous protein in mature bone. It is synthesized by osteoblasts and incorporated into bone matrix, although a fraction of the newly synthesized osteocalcin is released into the circulation. Metabolized mainly in the kidney and to a lesser extent in the liver, the half-life in the circulation is about five minutes. Osteocalcin production is dependent on 1,25 dihydroxy vitamin D; vitamin K; and vitamin C. Serum osteocalcin correlates with bone formation. It is increased in conditions characterized by increased bone turnover such as:• Hyperparathyroidism • Hyperthyroidism • Acromegaly • Paget's disease of bone. It is decreased in states such as: • Hypoparathyroidism • Hypothyroidism • Patients on glucocorticoid therapy. Although predominantly synthesized by osteoblasts, osteocalcin enters the circulation during bone resorption as well as formation, indicating rate of bone turnover.

  5. COl1 C-terminal telopepdtides level in serum

  6. Increased ALP, OC, CTX in serum implies bone turn over rate in Perk KO mice is elevated. ( Like Paget’s disease?) Next things to be done: • When will these first happen in Global Perk and Rip-perk Global KO? • Whether these phenotype will completely be recovered in Rip-perk Global KO? • Is there the same phenotype in conditional KO mice? • Look at the bone extract BALP level. • What about other bone marker? For example: PTH and calcium level in serum?

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