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Bone Formation and Bone Remodeling. S.K. Kim November 16, 2009. 46HE (H & E). Intramembranous bone formation of maxilla (flat bone). Nasal cavity. Nasal cavity. Oral cavity. Nasal septum (hyaline cartilage). Tongue. 46M ( Masson or Trichrome).
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Bone Formationand Bone Remodeling S.K. Kim November 16, 2009
46HE (H & E) Intramembranous bone formation of maxilla (flat bone) Nasal cavity Nasal cavity Oral cavity Nasal septum (hyaline cartilage) Tongue
46M (Masson or Trichrome) Mandibular bone (flat) formation: Intramembranous ossification Rotate 180o Tongue (skeletal muscle) Forming tooth Forming mandibular bone Meckel’s cartilage (hyaline) Genioglossus muscle (skeletal muscle) Lower jaw
#120 Developing face (frontal section) Forming facial (maxillary) bone: Intramembranous ossification Nasal cavity Orbit: eye ball Oral cavity Tongue Nasal septum: (hyaline cartilage)
Intramembranous bone formation. #46-HE; #46-M; #120 Bone trabecula(e) or spicules Periosteum
Bone Cells Osteoid ? #3 ? #1 Periosteum ? #2 Osteoblasts ? #5 Osteoclasts Osteocytes ? #4
115N (H&E)Sagital section of the palate 115-M (Masson) Rotate 180o Developing tooth Nasal cavity Upper lip Oral cavity Intramembranous, palatal and maxillary bone formation Gingiva (gum)
Immature (woven/mottled) bone; #115N Highly cellular: aggregation of osteocytes Basophilic: high concentration of GAGs
#115N Sharpey’s fibers
Growth in diameter of a long bone #48 (H&E) and 48b (Masson) Periosteum
Long bone shaft:growth in diameter #48 (tibia and fibula) Fibula Periosteum (Fibrous) (cellular) Tibia Osteoblasts Osteoid
#110 (finger, H&E) Endochondral Bone formation Epiphysis Metaphysis Diaphysis Epiphyseal plate
Epiphyseal plate and endochondral bone formation #108 (3) Chondrocyte hypertrophy Cartilage calcification (4) Erosion of calicified cartilage and bone deposition (ossification) (5) (1) Resting cartilage (2) Chondrocyte proliferation Tide mark