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Cytokine Signaling

Cytokine Signaling. Types of receptors . Protein tyrosine kinase receptors with intrinsic kinase activity Insulin, EGF, PDGF, CSF-1 etc. Protein serine kinase receptors with intrinsic kinase activity MIS, TGF b , activin, inhibin etc. Receptors without intrinsic kinase activity

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Cytokine Signaling

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  1. Cytokine Signaling

  2. Types of receptors • Protein tyrosine kinase receptors with intrinsic kinase activity • Insulin, EGF, PDGF, CSF-1 etc. • Protein serine kinase receptors with intrinsic kinase activity • MIS, TGFb, activin, inhibin etc. • Receptors without intrinsic kinase activity • This is the large, heterogeneous group called the cytokine receptor super family • G-protein coupled receptors and ion-gated receptors

  3. Types of receptors

  4. Protein tyrosine kinase receptors

  5. PTK receptor activating MAP kinase pathway

  6. PTK receptor activating Pi-3 kinase pathway

  7. SH2 domain containing protein: recognition of phosphotyrosines

  8. PTK signaling: 1o and 2o signals

  9. Cytokine signaling mechanisms • Cytokines represent a diverse number of molecules. • The super family of cytokine receptors more specifically refers to those cytokines that signal via the Jak-STAT pathway • These include Interleukins 2, 3, 4, 5, 6, 7, 9, 11, 12, 13, & 15, and G-CSF, LIF and the interferons • In addition, growth hormone, prolactin, erythropoietin, leptin, thrombopoietin • Many growth factor signal pathways cross-communicate with the STAT pathway.

  10. General scheme for all MAP-kinase pathways

  11. Receptor activation of intracellular signaling pathways

  12. PTK vs. cytokine pathways

  13. G-protein coupled receptors

  14. Cytokines and Leydig cells Immune-Endocrine control of Leydig cell function Overview and significance of Immune-endocrine interactions in the regulation of Leydig cell function

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