The Novel Tablet

1. The Novel Tablet

2. The Contributors • Research contributors: • Dr. Jim Ayres • Inventor, OSU College of Pharmacy • Dr. Mark Christensen • Inventor, OSU College of Pharmacy • Bill Newman • Mentor, Hewlett-Packard • Commercialization Plan by: • Sarah Fister • Merchandising Management • Jimmy Neyhart • Business Administration • Carly Stoughton • Computer Science Contributors Problem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

3. The Problem • An effective, long-lasting drug delivery system does not exist • Customers are inconvenienced by taking multiple doses throughout the day • Current drug delivery systems are inconsistent in their dosage administration Contributors Problem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

4. The Solution “Mean fever reductions and mean acetaminophen concentration in saliva. Observed temperature and mean acetaminophen concentration over time were observed in different groups of children. Open circles, mean acetaminophen concentration in saliva of children who absorb acetaminophen slowly…closed squares mean fever reduction” – U.S. Patent #5,766,623 ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

5. The Description • Novel Tablets provide 12-16 hours of steady dosage of active compound The tablets consist of: “A chewable tablet made from drug delivery pellets, each drug delivery pellet comprising: a core portion comprising an active agent; and a coating for the core portion, the coating and core portion forming a discrete body, the coating comprising a hydrophilic gel-forming agent undercoating or mixed with a polymeric rate-controlling material”. (U.S. Patent #5,766,623) ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

6. The Description 12 = active agent 20 = hydrophilic gel-forming agent layer 22 = polymeric rate-controlling material layer *** An additional layer (not shown) of binder, disintegrant, and flavor is added over layer 22 ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

7. The Benefits • 12-16 hour relief • Chewable, good-tasting tablet • Inexpensive • Manufactured with existing equipment • Patent secured – ready to go • FDA-approved ingredients • Most drug molecules compatible • Few direct competitors ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

8. Why License? • Given current industry developments, we must commercialize soon. Licensing is the most time effective, cost effective solution • First-mover advantage • IP protected via patent • Pharmaceutical drug patent extensions ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

9. Licensee Criteria • Company interested in R&D investment • Licensee open to innovative ideas • Has an entrepreneurial spirit • US roots with worldwide expansion • Segments in OTC and pharmaceutical markets ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

10. The License • Exclusive five year license • Cost of license = $1.5 billion • Royalty fees based on net sales • Licensee responsible for patent maintenance fees ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

11. The Opportunity • Works with virtually any prescriptive molecule: • Cardiovascular: • Hypertensives: Coreg • Respiratory • Histamines: Advair ContributorsProblem Solution Description Benefits Why License License Details Opportunity Financials Future Novel Tablet

12. GlaxoSmithKline Financials • Projections based on: • 10% additional premium per tablet • 3% additional growth for the following year • Implementation of the Novel Tablet delivery system ContributorsProblem Solution Description Benefits Why License License Details Opportunity Financials Future Novel Tablet

13. The Future: Near • Large over-the-counter market • The longest lasting drug on the market is Tylenol-8; not a constant dosage • Novel Tablets can be combined with a variety of medications • Useful for chronic pain (i.e. back pain, headaches) • Reduces amount people have to take in a day • No other drug on the market provides relief this long ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

14. The Future: Near: Issues • Competitors • Consumer adaptability ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

15. The Future: Further • Drug cocktails • Custom drug combinations • Infinite possibilities ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet

16. Acknowledgements Dr. Jim Ayers Inventor Dr. Mark Christenson Mentor; College of Pharmacy Ray Dandeneau Mentor Bill Newman Mentor; Hewlett Packard John Turner Professor Oregon State University ContributorsProblem Solution Description Benefits Why License License Details OpportunityFinancials Future Novel Tablet