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1. Mechanism and Scope of Palladium-Catalysed C-N and C-O Bond Formation A Presentation by Matthew Helm
3. First Intermolecular Carbon-Nitrogen Bond Formation
4. First Intramolecular Carbon-Nitrogen Bond formation
5. Catalytic examples using amino stanannes
6. Catalytic examples using amino stanannes
7. Achieving the Same Chemistry Without the use of Tin Reagents?
8. Achieving the Same Chemistry Without the use of Tin Reagents?
9. Intramolecular Cyclisations.
10. Catalyst Development
11. BINAP Reaction Mechanism
12. Catalyst development Concepts highlighted by Hartwig:
“The catalytic cycle involves bis-(phosphine) intermediates”
“Sterically encumbered phosphines are not necessary for high-yielding , intermolecular amination of aryl halides”
“Favourable selectivity for reductive elimination over b-hygrogen elimination results from chelation and large bite angle, rather than from steric effects”
13. Mechanistic Aspects
14. Coupling of Secondary Acyclic Amines
15. Coupling of Aryl Triflates
16. N-Allylation of Anilines Using Allyl Alcohols
17. Intermolecular Markovnikov Hydroamination of vinylarenes with alkylamines
18. Sequential Petasis Reaction / Palladium Catalysed Carbonylation / Amination Process
19. Sequential Petasis Reaction / Palladium Catalysed Carbonylation / Amination Process
20. Synthesis of Enamines and Imines
21. Other Developments Palladium catalysed carbon-nitrogen have been achieved using resin bound techniques: Examples using resin bound aryl halides and aryl amines have shown for Buchwald-Hartwig coupling. Other processes including asymmetric allylic amination have been achieved using resin-supported Palladium complexes.
Buchwald-Hartwig reactions have been conducted using microwave chemistry.
The Hydroamination of amination of allenes using Palladium catalysis.
As well as Aryl Triflates, Aryl Nonaflates and Sulfonates.
Aqueous Amination has been demonstrated:
23. Carbon-Oxygen bond formation
24. Intermolecular C-O Bond Formation
25. Expansion of the Scope of the Reaction
26. Catalyst development
27. Catalyst Development
28. Catalyst Development
29. Room Temperature Catalytic Formation of Aryl Ethers
30. Room Temperature Catalytic Formation of Aryl Ethers
31. Oxygen Nucleophiles in Palladium Catalysed Allylic Substitutions
32. Addition of Acidic OH Groups across Dienes
33. Stereoselective Synthesis of Tetrahydrofurans
34. Stereoselective Synthesis of Tetrahydrofurans
35. Stereoselective Synthesis of Tetrahydrofurans
36. Natural Products
37. Natural Products
38. Natural Products
39. Reviews
