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Total Synthesis of Bryostatin 1. Brittany Wheeler Chemistry Department University of Maryland. J. Am. Chem. Soc. Keck, G. E.; Poudel , Y. B.; Cummins, T. J.; Rudra , A.; Covel , J.A. 2011, 133, 744-747. Gary E. Keck. Professor at the University of Utah, Salt Lake City, Utah.
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Total Synthesis of Bryostatin 1 Brittany Wheeler Chemistry Department University of Maryland J. Am. Chem. Soc. Keck, G. E.; Poudel, Y. B.; Cummins, T. J.; Rudra, A.; Covel, J.A. 2011,133, 744-747.
Gary E. Keck • Professor at the University of Utah, Salt Lake City, Utah. • Group interests focus on total synthesis of natural products that have biological interest such as anti-tumor activity. • Another interest is developing new synthetic methods to be used in synthesis of natural products.
History • Bryostatins were first isolated in the 1960’s by George Pettit from Bugulaneritina, a species of bryozoa (filter-feeding aquatic invertebrates). • 20 different kinds of bryostatins isolated • Strong protein kinase C regulators • Exhibit anti-cancer and anti-Alzheimer’s qualities • One gram of bryostatin can be extracted from one ton of Bugulaneritina synthesis is a research priority
