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Colloid An Introduction. Kausar Ahmad Kulliyyah of Pharmacy http://staff.iiu.edu.my/akausar. Contents. Colloidal System. Particle size below 1 m m High specific surface area Discrete particles dispersed in a different medium. Types of Colloids. Classification Based on Size.
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Colloid An Introduction Kausar Ahmad Kulliyyah of Pharmacy http://staff.iiu.edu.my/akausar Physical Pharmacy 2
Contents Physical Pharmacy 2
Colloidal System • Particle size below 1 mm • High specific surface area • Discrete particles dispersed in a different medium Physical Pharmacy 2
Types of Colloids Physical Pharmacy 2
Classification Based on Size Physical Pharmacy 2
Classification of dispersed systems Physical Pharmacy 2
Colloidal Phenomena Physical Pharmacy 2
Pharmaceutical suspensions Physical Pharmacy 2
Preparing a Dispersion Physical Pharmacy 2
Properties of dispersing agents END OF LECTURE 1 OF 2 Physical Pharmacy 2
Pharmaceutical Emulsions Physical Pharmacy 2
Emulsification emulsifier homogeniser OIL WATER Physical Pharmacy 2
Emulsification Factors Physical Pharmacy 2
Types of Emulsions Physical Pharmacy 2
Nanoemulsion and Microemulsion Physical Pharmacy 2
Methods of Preparation Physical Pharmacy 2
Multiple Emulsion Physical Pharmacy 2
Example of w/o/w emulsion for drug delivery by intra-muscular route Physical Pharmacy 2
Multiple Emulsion for PharmaceuticalsExamples Sandostatin LARTM Depot • Novartis (hypothalamic hormones analogue) • Control of hypersecretion at the site of the tumour where hormone overproduction starts Human NutropinTM Depot • Alkermes/Genentech (human insulin suspension) • somatropin (rDNA origin) for injectable suspension • long-acting dosage form of recombinant human growth hormone (rhGH). Physical Pharmacy 2
Multiple emulsion Pharmaceutical Problems Physical Pharmacy 2
References PC Hiemenz & Raj Rajagopalan, Principles of Colloid and Surface Chemistry, Marcel Dekker, New York (1997) HA Lieberman, MM Rieger & GS Banker, Pharmaceutical Dosage Forms: Disperse Systems Volume 1, Marcel Dekker, New York (1996) F Nielloud & G Marti-Mestres, Pharmaceutical Emulsions and Suspensions, Marcel Dekker, New York (2000) J Kreuter (ed.), Colloidal Drug Delivery Systems, Marcel Dekker, New York (1994) Physical Pharmacy 2