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M 30, A solid mass with calcification and cystic space on left lung base

M 30, A solid mass with calcification and cystic space on left lung base. Chondroid Hamartoma. Chondroid Hamartoma. Chondroid Hamartoma.

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M 30, A solid mass with calcification and cystic space on left lung base

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  1. M 30, A solid mass with calcification and cystic space on left lung base Chondroid Hamartoma

  2. Chondroid Hamartoma

  3. Chondroid Hamartoma

  4. Definition: Benign neoplasmscomposed of varying proportions of mesenchymal tissues, such as cartilage, fat, connective tissue and smooth muscle, typically combined with entrapped respiratory epithelium. Histogenesis: Histogenesis is unknown, although genetic studies indicated a neoplastic rather than hamartomatous origin Somatic genetics: Pulmonary hamartomas have a high frequency of genetic mutations, similar to those seen in other benign mesenchymal neoplasmssuch as lipomas. Most notable are mutations of high-mobility group (HMG) proteins, a family of non-histon, chromatin-associated proteins, which are important in regulating chromatin architecture and gene expression. Mutation in the regions 6p21 and 12q14-15 are most commonly found.

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