1 / 33

Particle Beams for Cancer Therapy: From Physics to Daily Life

Explore the history of particle accelerators and their applications in cancer therapy and diagnostics, from the discovery of Roentgen rays to the development of modern proton and carbon ion therapy. Learn about the contributions of scientists such as Ugo Amaldi, Marie Curie, Lawrence and Wilson, and the role of institutions like CERN and TERA Foundation.

jamieweber
Download Presentation

Particle Beams for Cancer Therapy: From Physics to Daily Life

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. From Physics to Daily Life Particle Beams for Cancer Therapy Ugo Amaldi TERA Foundation and Technische Universität Munchen

  2. 120 years of particle accelerators are the best demonstration… fundamentalphysics 1895 1898 three intertwined yarns 2014 therapy diagnostics Particle Beams for Cancer Therapy UA

  3. Curie radium The beginnings Roentgen rays fundamentalphysics 1895 1898 2014 therapy diagnostics Roentgen rays Roentgen rays Curie radium Marie Slodowska - Pierre Curie Particle Beams for Cancer Therapy UA

  4. About 15 years later Hess cosmic rays fundamentalphysics 1895 1898 1912 1913 2014 therapy diagnostics Coolidge tube Coolidge tube Particle Beams for Cancer Therapy UA

  5. Today every CT scanner uses a Coolidge tube Particle Beams for Cancer Therapy UA

  6. About 15 years later an American giant contributed to the three yarns Lawrence cyclotrons fundamentalphysics 1895 1898 1912 1913 1929 1932 2014 therapy diagnostics 1 MeV = 1 million electronvolts = 0.001 GeV Lawrence cyclotrons Lawrence cyclotrons Particle Beams for Cancer Therapy UA

  7. About 15 years later an American giant contributed to the three yarns Spiral trajectory of an accelerated particle 1 MeV = 1 million electronvolts = 0.001 GeV Particle Beams for Cancer Therapy UA

  8. Veksler-McMillan synchrotron Another 15 years jump forward Hansen linac fundamentalphysics 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy diagnostics Veksler-McMillan synchrotron Hansen linac Wilson proton therapy Particle Beams for Cancer Therapy UA

  9. Veksler-McMillan synchrotron Another 15 years jump forward Hansen linac fundamentalphysics 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy 1959: Veksler visits McMillan diagnostics Veksler-McMillan synchrotron Hansen linac Wilson proton therapy Particle Beams for Cancer Therapy UA

  10. The first electron linac above 1 MeV William W. Hansen 1947 linac for electrons 1.5 MeV at 3 GHz Particle Beams for Cancer Therapy UA

  11. electrons ‘Conventional’ radiotherapy: linear accelerators dominate X X Courtesy of Elekta 2000 patients/year every in 1 million inhabitants 1 treatment in 30 sessions Particle Beams for Cancer Therapy UA

  12. electrons ‘Conventional’ radiotherapy: linear accelerators dominate X X Courtesy of Elekta 2000 patients/year every in 1 million inhabitants 1 treatment in 30 sessions In the world radiation oncologists use 20 000 electron linacs 50% of all the existing accelerators Particle Beams for Cancer Therapy UA

  13. 70 years later VARIAN is still the market leader VARIAN was founded in 1948 by W. Hansen, Russell Varian and Sigmur Varian Particle Beams for Cancer Therapy UA

  14. 1946: ‘Bob’ Wilson proposal fundamentalphysics 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy Founder and first Director of FERMILAB (Chicago) 1967-1978 diagnostics Robert Wilson Lawrence PhD student Particle Beams for Cancer Therapy UA

  15. 27 cm tumour target Protons and ions spare healthy tissue 200 MeV protons 5000 MeV carbon ions PSI X rays protons or carbon ions Photons Protons Particle Beams for Cancer Therapy UA

  16. 27 cm tumour target Protons and ions spare healthy tissue 200 MeV protons 5000 MeV carbon ions PSI X rays protons or carbon ions Photons Protons RADIOTHERAPY HADRONTHERAPY Particle Beams for Cancer Therapy UA

  17. Comparison of the macroscopic dose distributionsbetween X rays and protons Particle Beams for Cancer Therapy UA

  18. In the tumour target carbon ions produce CLUSTERED DOUBLE STRAND BREAKS and can control radioresistanttumours 4 carbon ion beams Particle Beams for Cancer Therapy UA

  19. 60 years ago: CERN creation and first proton therapy CERN fundamentalphysics 1953 1954 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy Berkeley proton therapy diagnostics CERN CERN Particle Beams for Cancer Therapy UA

  20. 60 years ago: CERN creation and first proton therapy fundamentalphysics 1953 1954 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy Berkeley proton therapy diagnostics Particle Beams for Cancer Therapy UA

  21. Proton therapy centers – with a cyclotron or a synchrotron and many rooms - proliferate gantry IBA 230 Mev cyclotron Courtesy of Elekta Particle Beams for Cancer Therapy UA

  22. Proton therapy centers – with a cyclotron or a synchrotron and many rooms - proliferate gantry IBA protontherapy is booming 230 Mev cyclotron Courtesy of Elekta Particle Beams for Cancer Therapy UA

  23. HIMAC in Chiba is the pioneer of carbon therapy YasuoHirao HirohikoTsujii 8500 pts 1994-2014 Particle Beams for Cancer Therapy UA

  24. Contributions of CERN to the red yarn Particle Beams for Cancer Therapy UA

  25. In 1995 U.A. and M. Regler convinced CERN to start Proton Ion Medical Machine Study, PIMMS Optimized synchrotron for therapy Project Leader: Phil Bryant Chair of PAC: Giorgio Brianti 1996-2000 M. Regler Particle Beams for Cancer Therapy UA

  26. linacs for carbon ions and protons In 1995 U.A. and M. Regler convinced CERN to start Proton Ion Medical Machine Study, PIMMS Contributors: CERN TERA Foundation (Italy); MedAustron Project (Austria) M. Regler Particle Beams for Cancer Therapy UA

  27. The Italian National Centre for Hadrontherapy CNAO has been designed by TERA and built in Pavia by CNAO Foundation Particle Beams for Cancer Therapy UA

  28. The Italian National Centre for Hadrontherapy CNAO has been designed by TERA and built in Pavia by CNAO Foundation beam September 2014: 300 pantients treated Particle Beams for Cancer Therapy UA

  29. MedAustron promoted and participated in PIMMS MedAustron in Wiener Neustadt Particle Beams for Cancer Therapy UA

  30. MedAustron promoted and participated in PIMMS Construction completed in Wiener Neustadt: Two weeks ago protons have been accelerated in the synchrotron Particle Beams for Cancer Therapy UA

  31. Second TERA program: linacs for protontherapy Basic unit: half-cell LIBO = LInacBOster for protons similar to an electron linac has accelerated particles from 62 MeV to 74 MeV Particle Beams for Cancer Therapy UA

  32. Centre offered by A.D.A.M. – a CERN spin-off Company acquired in 2013 by Advanced Oncotherapy SCDTL LIGHT RFQ CCL LInac for Image Guided Hadron Therapy 1 150 MeV 2 230 MeV 3 230 MeV Particle Beams for Cancer Therapy UA

  33. Office for CERN Medical Applications 1st January 2014 Steve Myers To conclude: in 2014 CERN has made a further step fundamentalphysics 2012 2014 1953 1954 1945 1947 1895 1898 1912 1913 1929 1932 2014 therapy CERN diagnostics CERN CERN Particle Beams for Cancer Therapy UA

More Related