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Transmissible Spongiform Encephalopathies (Prion disorders)

Transmissible Spongiform Encephalopathies (Prion disorders). Forms of Transmissible Spongiform Encephalopathy. Scrapie Creutzfeldt-Jakob disease Gerstmann-Straussler-Scheinker syndrome Kuru BSE vCJD nvCJD. All associated with PRIONS.

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Transmissible Spongiform Encephalopathies (Prion disorders)

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  1. Transmissible Spongiform Encephalopathies(Prion disorders)

  2. Forms of Transmissible Spongiform Encephalopathy • Scrapie • Creutzfeldt-Jakob disease • Gerstmann-Straussler-Scheinker syndrome • Kuru • BSE • vCJD • nvCJD All associated with PRIONS

  3. Animals Effected by Transmissible Spongiform Encephalopathy • Sheep, goats, deer, elk, mink, domestic cats, zoo species, cattle and humans

  4. BSE • First seen in UK in 1986 • Linked to cattle food supplemented with rendered offal from slaughtered sheep • Perhaps stimulated and amplified by the use of air embolus to slaughter cattle (captive bolt gun) Both are temporally related to the advent of BSE

  5. Prions • Proteinaceous infectious particle • Discovered by Dr. Stanley Prusiner • Prusiner awarded 1997 Nobel prize for physiology/medicine • Protein composition • Apparently capable of self reproduction • Contains no DNA or RNA • Very resistant to high temperatures and disinfection

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