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lnsulin Receptor Pathway

INSULIN. Fyn. Nck. SHC. GRB2. GLUT4. SOS. IRS1. Flotillin. Crk. Ras. GTP. CAP. Rab4. PI3K. GRB10. APS. GLUT4 Vesicle. Raf. IRS1/2. SHC. PPtase1. c-CbI. MEKs. Akt PKB. Rac. Insulin. JNK. PDK. PKC. mTOR. Insulin. P. P. P. P. P. P. P. P. P. P. P. P. P. P.

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lnsulin Receptor Pathway

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  1. INSULIN Fyn Nck SHC GRB2 GLUT4 SOS IRS1 Flotillin Crk Ras GTP CAP Rab4 PI3K GRB10 APS GLUT4Vesicle Raf IRS1/2 SHC PPtase1 c-CbI MEKs AktPKB Rac Insulin JNK PDK PKC mTOR Insulin P P P P P P P P P P P P P P P P P P P ERKs GlycogenSynthase BAD EAI EAI GSK3 p70S6K eIF4EBP FKHRL1 EEF2K c-Jun BAD 14-3-3 eIF2B c-Fos EEF2 eIF4 S6 Elk c-CbI Glucose PIP2 PIP3 Lipid Raft InsulinReceptor GLUT4Translocation lnsulin Receptor Pathway PIP2 PIP3 ReceptorInternalization H+ Insulin Degradation& ReceptorDephosphorylation H+ ATP Citrate lyase EBS Translation Translation Anti-apoptosis Fatty AcidSynthesis GeneExpression TRE Gene Expression

  2. INSULIN Fyn Nck SHC GRB2 GLUT4 IRS1 Flotillin Crk CAP Rab4 PI3K APS GLUT4Vesicle IRS1/2 SHC c-CbI Rac Insulin JNK PKC Insulin P P P P P P P P P P P P P P P P P GlycogenSynthase EAI EAI c-Jun c-Fos c-CbI Glucose Lipid Raft PIP2 PIP3 InsulinReceptor Cell membrane GLUT4Translocation lnsulin Receptor Pathway.A SIMPLIFIED VERSION PIP2 PIP3 ReceptorInternalization H+ Insulin Degradation& ReceptorDephosphorylation H+ Nucleus Fatty AcidSynthesis Translation Gene Expression Anti-apoptosis Translation GeneExpression TRE

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