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Ras-Raf-MAPK

P. P. P. P. P. P. Ras. SOS1. SHC. Grb2. Raf1. MEK1. MEK2. ERK1. ERK2. Ras-Raf-MAPK. Grb2, growth factor receptor-bound protein 2 . P. P. P. P. P. P. P. P. P. P. Ras. SOS1. SHC. Grb2. Raf1. MEK1. MEK2. Transcription. ERK1. SRF. SRF. ERK2. Ras-Raf-MAPK.

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Ras-Raf-MAPK

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  1. P P P P P P Ras SOS1 SHC Grb2 Raf1 MEK1 MEK2 ERK1 ERK2 Ras-Raf-MAPK Grb2, growth factor receptor-bound protein 2

  2. P P P P P P P P P P Ras SOS1 SHC Grb2 Raf1 MEK1 MEK2 Transcription ERK1 SRF SRF ERK2 Ras-Raf-MAPK Transcription factors Grb2, growth factor receptor-bound protein 2; SRF, serum response factor

  3. P P P P P P P Ras Raf1 MEK1 MEK2 Transcription ERK1 SRF SRF ERK2 Attivazione costitutiva di Ras-Raf-MAPK Ras

  4. Zarnestra (Tipifarnib, R115777) Sarasar (Lonafarnib, SCH66336)

  5. EVIDENCE FOR A Ras-INDEPENDENT EFFECT FOR FTIs • Lack of correlation between susceptibility and Ras status • Differences in the kinetics of development of the effects • Inhibition of K-Ras- and N-Ras-dependent cell growth

  6. REOVIRUS (Respiratory Enteric Orphan Virus)

  7. P P P P P P P Ras Raf1 MEK1 MEK2 Transcription ERK1 SRF SRF ERK2 Attivazione costitutiva di Ras-Raf-MAPK Ras

  8. SORAFENIB (Nexavar®): Low molecular weight inhibitor of VEGFR, PDGFR, KIT, RET and Raf-1 kinase activity

  9. Mechanism of action of sorafenib

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