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AP-1/ NF k B SAPK/ MAPK Proto-Oncogenes (e.g. Ras)

PTEN p53 p21. bcl-2 FLIP SUMO-1. XII. XI. I. Matrix Destruction. Attachement. X. II. AP-1/ NF k B SAPK/ MAPK Proto-Oncogenes (e.g. Ras). a3b1 (VLA-3) a4b1 (VLA-4) a5b1 (VLA-5) VCAM-1. IX. III. Cell cycle. VIII. IV. RASF. VII. V. VI. NF k B. Cytokine-dependent.

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AP-1/ NF k B SAPK/ MAPK Proto-Oncogenes (e.g. Ras)

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  1. PTENp53 p21 bcl-2 FLIPSUMO-1 XII XI I Matrix Destruction Attachement X II AP-1/ NFkB SAPK/ MAPKProto-Oncogenes (e.g. Ras) a3b1 (VLA-3) a4b1 (VLA-4) a5b1 (VLA-5) VCAM-1 IX III Cell cycle VIII IV RASF VII V VI

  2. NFkB Cytokine-dependent Cytokine-independent microparticles various mediators TNFa, IL-1, … TLRs Ras/Raf MAPK/STAT Akt MAPK/STAT NFkB IkB JNK ERK p38a/b p38d NFkB AP-1 AP-1 NFkB L1-elements MMPs / Chemokines pro-inflammatory/ anti-apoptotic genes  MMPs / Chemokines pro-inflammatory/ anti-apoptotic genes  progressive joint destruction

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