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???? ??? ?? ??? ??. 1. ???? ???? ??????? : K-Betest AUCt, Cmax, Tmax2. PK parameter ? ?? : WinNonlin AUCinf(CLtotal), Kel(t1/2), Ka, Vd/F, AUCt/AUCinf3. Population PK analysis : NONMEM Factors : Sex, Weight(height), Alcohol, Caffeine etc.4. PK/PD modeling : ADAPT PK data ?
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