K. Van Liempt Faculty of Medicine

1. The University of Antwerp Faculty of Medicine University Hospital Antwerp K. Van Liempt Faculty of Medicine

2. The Antwerp Region • 470.000 people in the City of Antwerp • Most important economic region in Flanders • Strong economic assets: • Port of Antwerp 2nd largest in Europe; 4th world-wide • Largest cluster of petrochemical industry in the world • Diamond trade • Logistics

3. The University of Antwerp • Founded in 2003 upon the merger of three independent University Institutions • Roots dating back to 1852 UIA RUCA UFSIA

4. The University of Antwerp in Flanders

5. The University of Antwerp in the World • University Rankings • QS World University ranking : 179 worldwide • ARWU (“Shanghai”) : 201-300 worldwide • Consistently in the top 250 worldwide

6. Facts and Figures • Main partner in the Antwerp University Association • 1 university (UA) • 4 university colleges • 30 000 students in total • 400 FTE UA-faculty staff • 1200 UA-research staff • 1100 UA-PhD students • Around 3500 scientific works published/year • 1500 articles in Web of Science/year

7. Natural Sciences Sciences Organisational Structure Humanities and Social Sciences Life Sciences AppliedEconomics Pharmaceutical, Biomedical and Veterinary Sciences Arts and Philosophy Medicine 7 Faculties Law Political and Social Sciences

8. Harbour, Transport and Logistics Imaging Social Economic Policy and Organisation Neurosciences Urban History and Contemporary Urban Policy Infectious Diseases Ecology and Sustainable Development Drug Discovery and Development Materials Characterisation Front Line Research Domains

9. Front Line Research Domains Harbour, Transport and Logistics Imaging Social Economic Policy and Organisation Neurosciences Urban History and Contemporary Urban Policy Infectious Diseases Ecology and Sustainable Development Drug Discovery and Development Materials Characterisation

10. Imaging EGAMI: Expert Group Antwerp Molecular Imaging Network of research labs Biomedical Microscopic Imaging Bioimaging Lab Molecular Imaging Center Antwerp (MICA) MicroCT Lab Vision Lab Links with Antwerp University Hospital (UZA) Radiology Nuclear Medicine

11. Imaging Molecular and CellularImaging Small Animal Imaging Clinical Imaging μMRI μPET Light Microscopy MRI μCT PET/SPECT (Scanning) Electron Microscopy Confocal Microscopy In Vivo Biolumi-nescence and Fluorescence Camera Fluorescence Microscopy CT Confocal Live Cell Imaging Image Processing Electrophysiology Image Processing Advanced Immuno-histochemistry 10

12. Imaging

13. Molecular Imaging Center Antwerp (MICA) Partnership between UA – UZA – Janssen Pharmaceutica Cyclotron + μPET/CT: micro-radiotherapy (320 keV), autoradiography, direct access to FDG, FLT, FET and possibility to produce research tracers, kinetic modeling, multimodal image registration Fully operational spring 2011 Imaging - Highlight

14. Front Line Research Domains Harbour, Transport and Logistics Imaging Social Economic Policy and Organisation Neurosciences Urban History and Contemporary Urban Policy Infectious Diseases Ecology and Sustainable Development Drug Discovery and Development Materials Characterisation

15. Neurosciences Neuronal Degeneration Neuronal Plasticity Neuronal Repair/ Replacement Cognition and Behaviour Neurogenetics Stem Cells Neurogenetics Stem Cells Neurobiology Song Birds Rodent Models Neuronal Tissue Engineering Neuro-pathology Psychiatric Disorders/ Dementia Nano-technology Biobank/ Biomarkers 14

16. Neurosciences in vivo ex vivo / in vitro < cell cell tissue organism

17. Neurosciences - Highlight VIB Department of Molecular Genetics (VIB8)(Director: Prof. Dr. Christine Van Broeckhoven) Genetic analysis of complex neurological and neuropsychiatric diseases To identify novel molecular mechanisms for disease causation and effective drug treatment for these diseases 4 research groups Neurodegenerative Brain Diseases Peripheral Neuropathies Neurogenetics Applied Molecular Genomics 2 centralized service facilities Diagnostic Service Facility Genetic Service Facility

18. Front Line Research Domains Harbour, Transport and Logistics Imaging Social Economic Policy and Organisation Neurosciences Urban History and Contemporary Urban Policy Infectious Diseases Ecology and Sustainable Development Drug Discovery and Development Materials Characterisation

19. Multidisciplinary research on infectious diseases and vaccines Focused on microbiology and immunology, with contributions of other disciplines Epidemiology Statistics/Mathematical modeling Sociology Economics Infectious Diseases 18

20. Infectious Diseases Preclinical Research Clinical Research Basic Research Immune System Biomarkers Diagnostic Tests Disease Mechanisms Vaccines Vaccines Antibiotic Resistance Injection Devices Prevention Epidemiology

21. Infectious Diseases - Highlights Antibiotic use and resistance European Surveillance of Antimicrobial Consumption (ESAC) European project coordinated by Prof. Dr. Herman Goossens of the UA Funded by the European Centre for Disease Prevention and Control (ECDC) 34 participating countries Study of the use of antibiotics, antivirals and antimycotics and occurrence of resistance A vaccine against leukemia? Wilms’ tumor 1 antigen-targeted dendritic cell vaccination against acute myeloid leukemia Van Tendeloo et al., PNAS, 2010

22. Front Line Research Domains Harbour, Transport and Logistics Imaging Social Economic Policy and Organisation Neurosciences Urban History and Contemporary Urban Policy Infectious Diseases Ecology and Sustainable Development Drug Discovery and Development Materials Characterisation

23. Drug Discovery and Development Target Discovery Drug Discovery Preclinical Drug Development End point: Clinical Trials Biomarkers DiseasePathology MedicinalChemistry Small Molecules Toxicity DiseaseMechanism Imaging Animal Models In vitroScreens MedicinalPlants 22

24. Major Focus of Disease Areas: Bone disease Osteoporosis Cancer Cardiovascular disease Atherosclerosis Infectious disease Bacterial, fungal and parasitic infections Kidney disease Metabolic disease Diabetes Drug Discovery and Development 23

25. Drug Discovery and Development - Highlight Antwerp Drug Discovery Network Integrated Platform for early drug discovery from hit to lead optimisation Protease Inhibitors Urokinase Plasminogen Activator (uPA) inhibitors in Oncology Molecular Probes as drug discovery tools Infectious Diseases In vitro screening panels for antifungals and drugs against tropical diseases Reference Center World Health Organization (WHO) 24

26. Overview number of students Medecine BA-MA 750 Nursing MA 194 Specialisation 250 Doctoral School 210 Physiotherapy 520 Total 1924 Faculty of Medicine 25

27. Faculty of Medicine • Features of medicaleducation • BA / MA structure • Competencedriven and student oriented teaching • Integration of CANMEDS roles in the curriculum aimed at transformingstudentsintomedical experts • English semester, Spring, 4th year

28. University Hospital Antwerp • Features of University Hospital • 600 beds • 520.000 consultations and technical activities • 300 MIO € yearly budget • Legally independent from University, but connected with several links, especially with the faculty of medicine • Close collaboration with regional hospitals