1 / 20

Hailey Myren Animal Science November 15, 2012

Changes in the Profile of Substances Related to Iron Metabolism During the Exercise and Training of Horses. . Hailey Myren Animal Science November 15, 2012. Introduction. Exercise Induced Iron Deficiency in Humans Exercise Induced Pulmonary Hemorrhage Supplementing Iron in Race Horses.

jean
Download Presentation

Hailey Myren Animal Science November 15, 2012

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Changes in the Profile of Substances Related to Iron Metabolism During the Exercise and Training ofHorses. Hailey Myren Animal Science November 15, 2012

  2. Introduction • Exercise Induced Iron Deficiency in Humans • Exercise Induced Pulmonary Hemorrhage • Supplementing Iron in Race Horses

  3. Important Terms • Hemolysis • Hemoglobin • Myoglobin • Ferritin • Total Serum Protein • Haptoglobin • TIBC

  4. Objectives • Determine the effect of exercise on substances related to the Iron profile of horses. • Determine if Iron supplementation is necessary to prevent anemia in exercising horses.

  5. Inoue et. al. (2002) • 4 TB’s • Standard Exercise Test (SET), 5 days • Moderate Intensity • Blood drawn from the jugular vein via catheter • Objective: study the changes of serum mineral concentration in horses during exercise.

  6. Inoue et. al. (2002) Values with different letters are significantly different (p<0.05) Pre means value before warming up Exercise means the value at the end of cantering

  7. Inoue (2002) Results • Blood Hb Increase • Hemoconcentration • Splenic Contraction • Increase in Fe, exact cause unknown • Prolonged Fe increase: • Hemolysis • Rhabdomyolysis • Fe levels remain within normal levels

  8. Kenyon, et. al. (2011) • 114 dogs -2007 Iditarod Dog Race • 59 - completed the race • 55- didn’t complete the race • Both male and females of different breeds • Objective—To determine effects of long-distance racing exercise on iron status in endurance racing sled dogs, with or without anemia.

  9. Kenyon, et. al. (2011) *Mean value was significantly different, compared with that of the prerace group. †Mean value was significantly different, compared with that of finishers.

  10. Kenyon, et. al. (2011) *Mean value was significantly different, compared with mean baseline value in the same dogs

  11. Kenyon (2011) Results • Ferritin levels higher in nonfinishers than finishers • Serum Fe: After race levels are lower than prerace levels in both groups • Serum Total Protein: decreased after exercise

  12. Inoue et. al. (2005) • 4 TB’s • 3 Week Training Program • Moderate, Relatively High, High Intensity • Blood, Urine, Feces, and Sweat Samples • Objective: Investigate Fe metabolism in horses during exercise.

  13. Inoue et. al. (2005) Values are mean +/- SE abc values with different letters= significantly different (p<0.05)

  14. Inoue (2005) Results • Reduced haptoglobin levels= hemolysis • Transferrin Saturation-reduction in Fe stores • TIBC- levels stable therefore no iron deficiency

  15. Inoue et. al. (2005) • Changes in Iron Absorption and Excretion into Urine and Sweat during the experiment • abc values with different letters= significantly different (p<0.05) • Abbreviations=ND=Not Determined, Iron balance=Apparent Absorption-Excretion into Urine-Excretion into Sweat

  16. Inoue (2005) Results • Urinary excretion no more than 1% of daily intake, minimal variation • Sweat excretion was no more than 5% of daily intake, minimal variation • Absorption of Fe increases, compensates for Fe loss during exercise

  17. Overview • Inoue (2002)- • Serum Fe increased after exercise, rhabdomyolysis • Kenyon (2011)- • Decrease in Serum Fe, building tissue or blood loss • Decreased Serum Protein- blood loss, proteins catabolized • Inoue (2005)- • Serum Fe decreasing-building muscle • Fe absorption increasing

  18. Final Conclusions • Exercise does not induce anemia in horses undergoing moderate, intense, or highly intense exercise • Since most diets provide excess Fe, increased Fe absorption will compensate for Fe losses and no supplementation is necessary

  19. Questions?

  20. References • Inoue, Y, A. Matsui, Y. Asai, F. Aoki, T. Matsui, and H. Yano. 2005. Effect of exercise on iron metabolism in horses. Biol. Trace Elem. Res. 107:33-42.    • Inoue, Y., T. Osawa, A., Matsui, Y. Asai, Y, Murakami, T. Matsui, and H. Yano. 2002. Changes of serum mineral concentrations in horses during exercise. Asian-australas. J. Anim. Sci. 15:531-536. • Jovanovic, M., V. Ilic, D. Trailovic, and D. Eureevic. 2007. The role of different iron preparations in the prevention of anemia in racing horses. Acta Vet (Beogr). 57:357-368. • Kenyon, C., R. Basaraba, and A. Bohn. 2011. Influence of Endurance Exercise on Serum Concentrations of Iron and Acute Phase Proteins in Racing Sled Dogs. J. Anim. Sci. 239:1201-1210. • Plumlee, K.H., B. Johnson, and I.A. Gardner. 1996. Heavy metal concentrations in injured racehorses. Vet. Hum. Toxicol. 38:204-206. • Schumacher, Y.O., A. Schmid, D. Konig, and A. Berg. 2002. Effects of exercise on soluble transferrin receptor and other variables of the iron status. Br. J. Sports Med. 36:195-199.

More Related