Joint Affiliation Agreement Between USF and the Johnnie B. Byrd, Sr. Alzheimer’s Center and Research Institute

1. Joint Affiliation Agreement Between USF and the Johnnie B. Byrd, Sr. Alzheimer’s Center and Research Institute Stephen Klasko, MD, MBA Senior VP, USF Health Dean, USF College of Medicine August 22, 2008

2. Common Vision: University of South Florida and Johnnie B. Byrd, Sr. Alzheimer’s Center and Research Institute seek to work collaboratively to conduct outstanding research with the goal of discovering a cure for Alzheimer's disease Primary Objectives: Enhance collaboration and synergy to accomplish Byrd’s State-wide mission in a timely manner Reduce administrative expenditures and increase Byrd’s reliance on extramurally funded research and patient care Byrd/USF Affiliation

3. 6-17-08 Term Sheet signed by Johnnie Byrd and Rhea Law 6-20-08 Term Sheet approved by Byrd Board 7-15-08 Joint Affiliation Named Byrd: Mr. Johnnie Byrd Ms. Kathy Harris Dr. Pamela Vergara USF: Dr. Wayne Goodman Dr. Karen Holbrook Mr. Frank Morsani Ms. Sherrill Tomasino 7-18-08 Joint Affiliation Board – initial meeting – all present Draft Affiliation Board (with minor revisions) adopted unanimously Sherrill Tomasino elected Chair Ex officio member added: Board of Governors Representative – Ann Duncan Byrd Timeline to Date

4. Dr. Potter has signed USF offer Senior Scientist at Byrd PI – ARDC grant Pfeiffer Chair in College of Medicine Tenured Professor Department of Molecular Medicine Affiliation Agreement between USF and Byrd Signed by President Genshaft Affirmed by USF BOT Dr. Potter’s Intellectual Property Internal review Additional update requested – 2005 forward External review initiated Byrd Timeline This Week

5. 8-22-08 Byrd Board ratifies and signs Affiliation Agreement Dr. Klasko named CEO of Byrd 8-25-08 Dr. Klasko meets with Byrd staff and introduces “Transition Team” Sept. ’08 Affiliation Board advised of progress of transition (completed actions and next steps) Oct. ’08 Affiliation Board and Byrd Board advised action plan (completed actions and additional steps – intermediate and longer term) Spring ’09 Byrd Statute revised consistent with Affiliation Agreement Byrd Timeline Moving Forward

6. An opportunity to create a USF/Byrd collaborative integrated Alzheimer’s research, patient care, education and community outreach program Potential for recruitment and co-location of premier basic and translational researchers to find a cure for Alzheimer’s disease Integration across USF Health/Byrd of clinical research and clinical care services for patients with Alzheimer’s disease and related memory disorders Enhanced potential for continued ADRC funding Better prospect of serving Byrd’s State-wide mission Potential – What is Exciting?

7. Resources in hand Current assets ($17M 6-30-08) Fixed assets ($37M 6-30-08) Projected Annual Income ($1M 6-16-08) Current Rate of Expenditures (unsustainable) Realities – Financial Challenges

8. Assess the Potential Address the Realities Provide Leadership Organize the Team Achieve the Goals My Responsibilities as a CEO are to:

9. Creative Educational Research Really Creative Educational Research Really Creative Educational Research Really Models Matters Models Matters Models Matters Strive for National Strive for National Strive for National Prominence Prominence Prominence True Collaboration: True Collaboration: True Collaboration: Entrepreneurial Academic Creative/Successful USF Health + COM + HSC + Practice Models Practice Models Practice Models University University University 2005 – Looking Ahead Blueprint for Strategic Action: These touchstones have guided decision-making aimed at national prominence: We will not invest in less.

10. Basic & Translational Research – Dr. Abdul Rao Clinical Research & Patient Care – Dr. Cliff Gooch Dr. Abdul Rao ADRC/Statewide Consortium – Consultant Byrd Transition Programmatic Review

11. John Ekarius, Joann Strobbe, Patricia Haynie Staffing Model/Mini Blue Print for Action – Rick Smith Finance – Leigh Ann Drexler Audit – Kate Head Human Resources – Sandy Lovins Plant/Facilities/Grounds – Joe Eagan Clinical/Patient Care – Ellen Pastizzo Information Technology – Jim McKenzie Research Compliance – Caroline Fultz-Carver Byrd Administrative Transition Team