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Names: Christopher Ding and James Jiang High Schools: Adams High School, Troy High School

Names: Christopher Ding and James Jiang High Schools: Adams High School, Troy High School Mentor: Dr. Michael Chopp Project Title: Inhibition of VEGF decreases photodynamic therapy-induced angiogenesis, and reduces tumor regrowth of nude mice bearing U87 human glioma.

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Names: Christopher Ding and James Jiang High Schools: Adams High School, Troy High School

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  1. Names: Christopher Ding and James Jiang • High Schools: Adams High School, Troy High School • Mentor: Dr. Michael Chopp • Project Title: Inhibition of VEGF decreases photodynamic therapy-induced angiogenesis, and reduces tumor regrowth of nude mice bearing U87 human glioma • The current prognosis for patients with malignant gliomas remains poor. Photodynamic therapy (PDT) has been clinically developed as an adjuvant local therapy for brain tumors. Nevertheless, the efficacy of PDT treatment of glioma remains unsatisfactory. In addition to an incomplete killing of tumor cells, a reason for the failure of PDT as an effective treatment of glioma may be attributed to PDT-induced angiogenesis. We propose to test the novel hypothesis that angiogenesis in non-tumor tissue induced by PDT independent of tumor, contributes to tumor growth. Therefore, therapeutic intervention to inhibit angiogenesis in adjacent non-tumor tissue will diminish the likelihood of tumor regrowth from residual tumor cells. Here, we test this hypothesis in a model of PDT-treated nude mouse bearing human glioma. Our data show that inhibition of VEGF signaling post-PDT treatment significantly reduces subsequent angiogenesis in brains of nude mice. We also report that inhibition of VEGF signaling in conjunction with PDT treatment significantly reduces tumor regrowth. Our results suggest that concomitant anti-angiogenic therapy represents an effective method of enhancing PDT therapy of brain tumor.

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